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Open Access Technical advance

Physiological relevance and performance of a minimal lung model – an experimental study in healthy and acute respiratory distress syndrome model piglets

Yeong Shiong Chiew1, J Geoffrey Chase1, Bernard Lambermont2, Nathalie Janssen3, Christoph Schranz4, Knut Moeller4, Geoffrey M Shaw5 and Thomas Desaive6*

Author Affiliations

1 Department of Mechanical Engineering, University of Canterbury, Christchurch, New Zealand

2 Medical Intensive Care Unit, University Hospital of Liege, Liege, Belgium

3 Emergency Department, University Hospital of Liege, Liege, Belgium

4 Institute for Technical Medicine, Furtwangen University, Villingen-Schwenningen, Germany

5 Department of Intensive Care, Christchurch Hospital, Christchurch, New Zealand

6 Thermodynamics of Irreversible Processes, Institute of Physics, University of Liege, Liege, Belgium

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BMC Pulmonary Medicine 2012, 12:59  doi:10.1186/1471-2466-12-59

Published: 21 September 2012

Abstract

Background

Mechanical ventilation (MV) is the primary form of support for acute respiratory distress syndrome (ARDS) patients. However, intra- and inter- patient-variability reduce the efficacy of general protocols. Model-based approaches to guide MV can be patient-specific. A physiological relevant minimal model and its patient-specific performance are tested to see if it meets this objective above.

Methods

Healthy anesthetized piglets weighing 24.0 kg [IQR: 21.0-29.6] underwent a step-wise PEEP increase manoeuvre from 5cmH2O to 20cmH2O. They were ventilated under volume control using Engström Care Station (Datex, General Electric, Finland), with pressure, flow and volume profiles recorded. ARDS was then induced using oleic acid. The data were analyzed with a Minimal Model that identifies patient-specific mean threshold opening and closing pressure (TOP and TCP), and standard deviation (SD) of these TOP and TCP distributions. The trial and use of data were approved by the Ethics Committee of the Medical Faculty of the University of Liege, Belgium.

Results and discussions

3 of the 9 healthy piglets developed ARDS, and these data sets were included in this study. Model fitting error during inflation and deflation, in healthy or ARDS state is less than 5.0% across all subjects, indicating that the model captures the fundamental lung mechanics during PEEP increase. Mean TOP was 42.4cmH2O [IQR: 38.2-44.6] at PEEP = 5cmH2O and decreased with PEEP to 25.0cmH2O [IQR: 21.5-27.1] at PEEP = 20cmH2O. In contrast, TCP sees a reverse trend, increasing from 10.2cmH2O [IQR: 9.0-10.4] to 19.5cmH2O [IQR: 19.0-19.7]. Mean TOP increased from average 21.2-37.4cmH2O to 30.4-55.2cmH2O between healthy and ARDS subjects, reflecting the higher pressure required to recruit collapsed alveoli. Mean TCP was effectively unchanged.

Conclusion

The minimal model is capable of capturing physiologically relevant TOP, TCP and SD of both healthy and ARDS lungs. The model is able to track disease progression and the response to treatment.

Keywords:
ARDS; Recruitment model; Animal trials; Mechanical ventilation