|Regression coefficients and odds ratios with 95% confidence intervals as derived from the original model and the internally validated model|
|Original model||Model after internal validation|
|Variable||Regression coefficient||Odds ratio (95% CI)||p-value||Regression coefficient*||Odds ratio (95% CI)|
|Elevated sIL-2R levels||1.98||7.27 (1.86 – 28.40)||0.004||1.85||6.33 (1.73-28.17)|
|Total HRCT score||0.24||1.27 (1.06 - 1.52)||0.011||0.22||1.25 (1.04-1.50)|
To calculate the absolute risk of a positive PET result:
P(PET-positive) = (1 / (1 + exp(-(-0.23 + 1.85 * sIL-2R + 0.22 * HRCT score)))) * 100%
CI: confidence interval; sIL-2R: soluble interleukin-2 Receptor; HRCT: high-resolution computed tomography; PET: positron emission tomography.
* Regression coefficients after adjustment for overfitting by shrinkage (shrinkage factor = 0.93); the intercept was re-estimated.
Mostard et al.
Mostard et al. BMC Pulmonary Medicine 2012 12:57 doi:10.1186/1471-2466-12-57