Table 6 |
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|
Risk of serious complications (S.C.) and death from smallpox re-vaccinations for ages greater than 1, 1963–1968 |
|||||||||
|
Complication and studies |
Number vaccinated |
S.C. No. |
Deaths No. |
Risk of complication per million (95% C.I.)a |
Risk of death per million (95% C.I.)a |
Case fatality risk per hundred (95% C.I.)a |
|||
|
|
|||||||||
|
Post-vaccinial encephalitis |
|||||||||
|
Neff 1967a |
7,775,000 |
0 |
0 |
0.0 |
(0.0, 0.5) |
0.0 |
(0.0, 0.5) |
n/a |
n/a |
|
Neff 1967b |
370,000 |
0 |
0 |
0.0 |
(0.0, 10.0) |
0.0 |
(0.0, 10.0) |
n/a |
n/a |
|
Lane 1969 |
8,574,000 |
0 |
0 |
0.0 |
(0.0, 0.4) |
0.0 |
(0.0, 0.4) |
n/a |
n/a |
|
Lane 1970 |
998,000 |
2 |
0 |
2.0 |
(0.2, 7.3) |
0.0 |
(0.0, 3.7) |
0.0 |
(0.0, 84.2) |
|
Mellin 1970 |
166,000 |
0 |
0 |
0.0 |
(0.0, 22.2) |
0.0 |
(0.0, 22.2) |
n/a |
n/a |
|
Ratner 1970 |
465,926 |
0 |
0 |
0.0 |
(0.0, 7.9) |
0.0 |
(0.0, 7.9) |
n/a |
n/a |
|
Neff 1972 |
433 |
0 |
0 |
0.0 |
(0.0, 8483) |
0.0 |
(0.0, 8483) |
n/a |
n/a |
|
Summary |
18,349,359 |
2 |
0 |
0.1 |
(0.01, 0.4) |
0.0 |
(0.0, 0.2) |
0.0 |
(0, 84.2) |
|
Vaccinia necrosum |
|||||||||
|
Neff 1967a |
7,775,000 |
2 |
0 |
0.3 |
(0.03, 0.9) |
0.0 |
(0.0, 0.5) |
0.0 |
(0.0, 84.2) |
|
Neff 1967b |
370,000 |
0 |
0 |
0.0 |
(0.0, 10.0) |
0.0 |
(0.0, 10.0) |
n/a |
n/a |
|
Lane 1969 |
8,574,000 |
6 |
2 |
0.7 |
(0.3, 1.5) |
0.2 |
(0.03, 0.8) |
33.3 |
(4.3, 77.7) |
|
Lane 1970 |
998,000 |
3 |
0 |
3.0 |
(0.6, 8.8) |
0.0 |
(0.0, 3.7) |
0.0 |
(0.0, 70.8) |
|
Mellin 1970 |
166,000 |
1 |
0 |
6.0 |
(0.2, 33.6) |
0.0 |
(0.0, 22.2) |
0.0 |
(0.0, 97.5) |
|
Ratner 1970 |
465,926 |
0 |
0 |
0.0 |
(0.0, 7.9) |
0.0 |
(0.0, 7.9) |
n/a |
n/a |
|
Neff 1972 |
433 |
0 |
0 |
0.0 |
(0.0, 8483) |
0.0 |
(0.0, 8483) |
n/a |
n/a |
|
Summary |
18,349,359 |
12 |
2 |
0.7 |
(0.3, 1.1) |
0.1 |
(0.01, 0.4) |
16.7 |
(2.1, 48.4) |
|
Eczema vaccinatum |
|||||||||
|
Neff 1967a |
7,775,000 |
3 |
0 |
0.4 |
(0.1, 1.1) |
0.0 |
(0.0, 0.5) |
0.0 |
(0.0, 70.8) |
|
Neff 1967b |
370,000 |
5 |
0 |
13.5 |
(4.4, 31.5) |
0.0 |
(0.0, 10.0) |
0.0 |
(0.0, 52.2) |
|
Lane 1969 |
8,574,000 |
8 |
0 |
0.9 |
(0.4, 1.8) |
0.0 |
(0.0, 0.4) |
0.0 |
(0.0, 36.9) |
|
Lane 1970 |
998,000 |
3 |
0 |
3.0 |
(0.6, 8.8) |
0.0 |
(0.0, 3.7) |
0.0 |
(0.0, 70.8) |
|
Mellin 1970 |
166,000 |
0 |
0 |
0.0 |
(0.0, 22.2) |
n/a |
n/a |
n/a |
n/a |
|
Ratner 1970 |
465,926 |
0 |
0 |
0.0 |
(0.0, 7.9) |
n/a |
n/a |
n/a |
n/a |
|
Neff 1972 |
433 |
0 |
0 |
0.0 |
(0.0, 8483) |
n/a |
n/a |
n/a |
n/a |
|
Summary |
18,349,359 |
19 |
0 |
1.0 |
(0.6, 1.6) |
0.0 |
(0.0, 0.2) |
0.0 |
(0.0, 17.6) |
|
Generalized vaccinia |
|||||||||
|
Neff 1967a |
7,775,000 |
3 |
0 |
0.4 |
(0.1, 1.1) |
n/c |
n/c |
n/c |
n/c |
|
Neff 1967b |
370,000 |
1 |
0 |
2.7 |
(0.1, 15.1) |
n/c |
n/c |
n/c |
n/c |
|
Lane 1969 |
8,574,000 |
10 |
0 |
1.2 |
(0.6, 2.1) |
n/c |
n/c |
n/c |
n/c |
|
Lane 1970 |
998,000 |
9 |
0 |
9.0 |
(4.1, 17.1) |
n/c |
n/c |
n/c |
n/c |
|
Mellin 1970 |
166,000 |
1 |
0 |
6.0 |
(0.2, 33.6) |
n/c |
n/c |
n/c |
n/c |
|
Ratner 1970 |
465,926 |
1 |
0 |
2.1 |
(0.05, 12.0) |
n/c |
n/c |
n/c |
n/c |
|
Neff 1972 |
433 |
0 |
0 |
0.0 |
(0.0, 8483) |
n/a |
n/a |
n/a |
n/a |
|
Summary |
18,349,359 |
25 |
0 |
1.4 |
(0.9, 2.0) |
n/c |
n/c |
n/c |
n/c |
|
Accidental inoculation |
|||||||||
|
Neff 1967a |
7,775,000 |
8 |
0 |
1.0 |
(0.4, 2.0) |
n/c |
n/c |
n/c |
n/c |
|
Neff 1967b |
370,000 |
250 |
0 |
675.7 |
(594, 765) |
n/c |
n/c |
n/c |
n/c |
|
Lane 1969 |
8,574,000 |
7 |
0 |
0.8 |
(0.3, 1.7) |
n/c |
n/c |
n/c |
n/c |
|
Lane 1970 |
998,000 |
42 |
0 |
42.1 |
(30.3, 56.9) |
n/c |
n/c |
n/c |
n/c |
|
Mellin 1970 |
166,000 |
3 |
0 |
18.1 |
(3.7, 52.8) |
n/c |
n/c |
n/c |
n/c |
|
Ratner 1970 |
465,926 |
1 |
0 |
2.1 |
(0.05, 12.0) |
n/c |
n/c |
n/c |
n/c |
|
Neff 1972 |
433 |
0 |
0 |
0.0 |
(0.0, 8483) |
n/a |
n/a |
n/a |
n/a |
|
Summary |
18,349,359 |
311 |
0 |
16.9 |
(15.1, 18.9) |
n/c |
n/c |
n/c |
n/c |
|
|
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|
n/a = not assessable, n/c = not calculated aExact confidence intervals based on the binomial distribution |
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|
Aragón et al. BMC Public Health 2003 3:26 doi:10.1186/1471-2458-3-26 |
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