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Open Access Research article

Latent tuberculosis infection in a Malaysian prison: implications for a comprehensive integrated control program in prisons

Haider Abdulrazzaq Abed Al-Darraji1*, Adeeba Kamarulzaman12 and Frederick L Altice123

Author Affiliations

1 Centre of Excellence for Research in AIDS, Faculty of Medicine, University of Malaya, Kuala Lumpur 59990, Malaysia

2 Department of Internal Medicine, Yale University School of Medicine, Section of Infectious Diseases, AIDS Program, New Haven, Connecticut, USA

3 Division of Epidemiology of Microbial Diseases, Yale University School of Public Health, New Haven, Connecticut, USA

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BMC Public Health 2014, 14:22  doi:10.1186/1471-2458-14-22


The electronic version of this article is the complete one and can be found online at: http://www.biomedcentral.com/1471-2458/14/22


Received:20 February 2013
Accepted:5 January 2014
Published:10 January 2014

© 2014 Al-Darraji et al.; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background

Prisons continue to fuel tuberculosis (TB) epidemics particularly in settings where access to TB screening and prevention services is limited. Malaysia is a middle-income country with a relatively high incarceration rate of 138 per 100,000 population. Despite national TB incidence rate remaining unchanged over the past ten years, data about TB in prisons and its contribution to the overall national rates does not exist. This survey was conducted to address the prevalence of latent TB infection (LTBI) in Malaysia’s largest prison.

Methods

From July to December 2010, all HIV-infected and a comparative group of HIV-uninfected prisoners housed separately in Kajang prison were asked to participate in the survey after explaining the study protocol. Subjects providing informed consent were interviewed using a structured questionnaire followed by the placement of tuberculin skin test (TST) with 2 TU of PPD RT-23 to subjects not being treated for active TB. TST was read after 48-72 hours and indurations of ≥ 5 mm and ≥ 10 mm were considered positive among HIV-infected and HIV-uninfected subjects, respectively. Additionally, HIV-infected inmates underwent phlebotomy for CD4 lymphocyte count assessment. A logistic regression model was explored to determine factors associated with TST positivity.

Results

Overall, 286 subjects (138 HIV-infected and 148 HIV-uninfected) had complete data and TST results. The majority were men (95.1%), less than 40 years old (median age 36.0, SD 7.87), and Malaysians (93.3%). Most (82.5%) had been previously incarcerated and more than half (53.1%) reported sharing needles just prior to their incarceration. TST was positive in 88.8% (84.7% among HIV-infected and 92.5% among HIV-uninfected subjects) and was independently associated with being HIV-uninfected (AOR = 2.97, p = 0.01) and with frequent previous incarcerations (AOR = 1.22 for every one previous incarceration, p = 0.01) after adjusting for other potential confounding factors.

Conclusions

The prevalence of LTBI was extraordinary high in this sample of Malaysian prisoners, regardless of their age or HIV status. This warrants further examination of the size of the problem of TB in other congregate settings and the establishment of an evidence-based TB control program in Malaysian prisons with integrated TB, HIV and substance abuse components.

Keywords:
Tuberculosis; HIV/AIDS; Prisons; Malaysia; Latent tuberculosis; Substance use disorders; Isoniazid preventive therapy; Integrated healthcare

Background

Globally, prisons represent a major institutional amplifier for tuberculosis (TB), particularly in low- and middle-income countries (LMICs) [1]. The congregated environment and the concentration of TB-related risk factors among prisoners alongside the inequity in health service provision in these settings promote TB transmission and progression, particularly drug-resistant forms [2], within and beyond their walls [3]. Prisoners have a disproportionately higher prevalence of socioeconomically disadvantaged individuals, including individuals who are homeless, HIV-infected, have substance use disorders and poor access to health services compared to the non-incarcerated community [4]. Moreover, poor ventilation, overcrowding, malnutrition and psychiatric distress are prevalent in prisons and contribute and compound TB transmission among inmates in these settings [3,5]. Globally, TB among prisoners is several-fold higher than that of the general population. As such, prisons serve as reservoirs that facilitate TB transmission to the general community through released inmates and prison staff, especially where transitional care is not adequate [6,7]. Increasing incarceration rates alone has contributed to the dramatic increase in the TB incidence and prevalence of multi-drug resistant TB (MDR-TB) in the communities of European and Central Asian countries [8,9]. A systematic review of assembled reports estimated that TB exposure within prisons was attributable to 8.5% and 6.3% of all TB cases in community settings in high- and low/middle-income countries, respectively [10]. Additionally, TB contributes significantly to prison-related mortality in LMICs [4].

Malaysia, a middle-income Asia-Pacific country whose populations exceeds 29 million, has an intermediate annual TB incidence of 82 cases per 100,000 population and a TB-attributed mortality rate of 8.5 per 100,000 population [11]. In parallel, people who inject drugs (PWIDs) contribute largely to the HIV epidemic in Malaysia, where more than three-quarter of HIV-infected individuals are PWIDs [12]. While the national HIV prevalence is 0.4%, the HIV prevalence in prisons (6%), where HIV testing is mandatory, is fifteen times higher [12,13]. The high HIV prevalence among prisoners is attributed to Malaysia’s harsh criminalization laws towards drug use, including growth in prisons and compulsory drug detention centers [14,15], and placing Malaysia among the countries with the highest incarceration rate (138 per 100,000 population) worldwide [13,14].

While places like Malaysia create the ideal setting for the negative interaction among HIV, TB and incarceration, little empiric data about TB in these settings are available and provide a rationale for assessing the prevalence and correlates of latent TB infection (LTBI) among HIV-infected and –uninfected inmates in Malaysia’s largest prison.

Methods

The cross-sectional tuberculin survey was conducted in Kajang prison, a high-security and the largest prison in Malaysia. Built to accommodate a maximum of 3500 inmates, the prison currently houses more than 4,000 inmates, operating at 119% of its actual capacity [16]. TB screening policies do not exist upon prison entry or thereafter and passive reporting of symptoms by ill inmates identifies active TB cases. Other TB control measures (e.g. TB preventive chemotherapy or infection control measures) are similarly not implemented in the prison. There are 11 separate prison units, each with different capacities, including one unit that segregates only HIV-infected prisoners. From July to December 2010, all HIV-infected inmates and a comparative group of HIV-uninfected prisoners from a similarly sized unit were voluntarily asked to participate in a tuberculin screening assessment. HIV testing is mandatory in Malaysian prisons and the 189 confirmed HIV-infected inmates in July 2010 were confined in segregated housing units in both men and women prisons. Of 189 HIV-infected prisoners, 138 had complete TST and survey data and were included in the analysis (Figure  1). A distinct housing unit for HIV-uninfected inmates was randomly selected from among 10 other units and served as a comparison group based on similar size where 151 inmates were housed. Of these, 148 had complete data. After delivering separate information sessions describing the study, interested prisoners were asked to provide informed consent. After consent, participants were interviewed using a structured questionnaire that contains sociodemographic data, incarceration history, HIV risk behaviors and any history of previous TB disease. In addition, participants were screened clinically for TB using the standardized World Health Organization (WHO) clinical scoring algorithm for prisons: cough for more than 2 weeks (2 points), sputum production (2 points), loss of weight (1 point) or appetite (1 point), and chest pain (1 point) [6]. Inmates reporting scores of 5 points or more were referred to prison health authorities for further active TB disease assessment. Due to the unavailability of TB diagnostic tools inside the prison, prisoners were referred to a nearby community hospital for further investigation, but transfer was at the discretion of prison authorities. Five HIV-infected subjects had WHO scores ≥5 had a normal chest radiograph and negative AFB microscopy and were ultimately enrolled in the study. For subjects not currently receiving active TB treatment, tuberculin skin test (TST) was placed intradermally using 2 TU RT-23 (Staten Serum Institut, Copenhagen, Denmark) and read after 48-72 hours by a single investigator (H.A.A.A). Indurations of ≥ 5 mm and ≥ 10 mm were considered positive for HIV-infected and HIV-uninfected participants, respectively [17]. All HIV-infected participants underwent phlebotomy for CD4 lymphocyte count assessment.

thumbnailFigure 1. Disposition of study participants.

Data were analyzed using SPSS v19 (IBM Corporation, Somers, NY, USA). Categorical variables were presented as frequencies and continuous variables were presented by median and standard deviation (SD) or interquartile range (IQR) depending on the normality of the variable distribution. Chi-square and student t-test were utilized to compare categorical and continuous variables, respectively between the two screened groups. The primary outcome of interest was TST positivity. Covariates associated with the primary outcome on univariate logistic analysis at p < 0.20 were subsequently included in the multiple logistic regression model and controlled for potential confounders.

The study protocol was reviewed and approved by the University of Malaya Medical Centre Ethics Committee. Participation was completely voluntary and subjects who refused to participate were not in any way disadvantaged. All interviews and collected data were kept confidential.

Results

Of the 340 recruited subjects, 286 participants (138 HIV-infected and 148 HIV-uninfected subjects) had complete data for analysis (Figure  1). The majority of participants were men (95.1%), less than 40 years old (median = 36.0, SD = 7.87 years), and ethnically Malay (93.3%). Most had completed primary education (68.8%) and were stably housed (82.1%) before being incarcerated. Nearly all were cigarette smokers (98.2%) and the majority (69.5%) drank alcohol before the current incarceration. More than half of all study participants (53.1%) reported sharing needles just prior to the current incarceration. The majority (82.5%) had been previously incarcerated for a median of 3.0 times (IQR 1-6) and a lifetime incarceration of 36 months (IQR 6-74). Nearly all (91.6%) were previously vaccinated with Bacille Calmette-Guerin (BCG) at least once, either during infancy or primary schooling, in accordance with former vaccination guidelines in Malaysia [18]. Despite being a high-risk group, the majority (92.0%) had never been previously screened for TB and 19 (6.6%) reported having received anti-TB treatment previously, but prior treatment could not be verified. Table  1 compares characteristics between HIV-infected and HIV-uninfected prisoners. Compared to those without HIV infection, HIV-infected participants were more likely to have pre-incarceration unstable housing (p = 0.005), have shared needles (p < 0.0001), have been previously incarcerated (p < 0.0001) and have been imprisoned for longer lifetime duration (p < 0.0001).

Table 1. Comparison of HIV-seropositive and HIV-seronegative prisoners (N = 286)

Among the HIV-infected prisoners, the median CD4 count was 384 (IQR 257-591) lymphocytes/μL; 23 (16.8%) subjects had CD4 lymphocyte count <200 cells/μL (AIDS-defining diagnosis and in need of preventive therapy against Pneumocystis jiroveci pneumonia) and 63 (45.6%) had CD4 ≤350 lymphocytes/μL (eligible for antiretroviral therapy; ART).

For the primary outcome, 88.8% (254 out of 286) were TST positive; 84.7% among HIV-infected and 92.5% among HIV-uninfected participants. The median size of reactive TST induration was 17 mm (SD = 6.9). After controlling for several characteristics in the bivariate analysis (see Table  2), independent correlates associated with TST positivity was being HIV-seronegative (AOR = 2.97, p = 0.01) and having been frequently incarcerated previously (AOR = 1.22 for every one previous incarceration, p = 0.01).

Table 2. Correlates of tuberculin skin test reactivity (N = 286)

Discussion

Globally, prisons represent major reservoirs for fuelling TB epidemics, particularly in LMICs [19]. To our knowledge, a reactive TST prevalence of 88.8% among Malaysian prisoners is the highest we have encountered in the literature to date. Moreover, we found that TST positivity was extraordinarily high, irrespective of age and HIV status.

Our findings differ markedly from other countries where economic status and national TB rates still affirm the disturbingly high prevalence of LTBI among prisoners. For example, TB surveys in other LMICs like Pakistan (48%) [20], Brazil (73%) [21] and Lebanon (45%) [22] showed high LTBI prevalence in prisons, primarily among predominantly HIV-seronegative or unknown HIV status participants, yet none of them approach LTBI prevalence found in Malaysia. Using different TST cut-offs and sampling method, TST screening among "contacts" of index TB cases with unknown HIV status in a Singaporean prison (a high-income Asia-Pacific country) showed higher prevalence of TST positivity compared to a contact screening in the community [23]. In other high-income countries, prison-based TB screening programs varied considerably, with highest LTBI prevalence in Spain (40.3% and 62%) [24,25] and Switzerland (46.9%) [26] and lowest in Italy (17.9%) [27] and the United States (17%) where HIV status was unknown [28]. The higher prevalence findings from Spain and Switzerland were partially explained by the high proportion of international migrants (foreign-born) from LMICs with high TB incidence.

While studies elsewhere have reported LTBI prevalence among prisoners in various international settings, most have not systematically assessed for independent correlates associated with LTBI. The present study expands previous findings by not only reporting the extraordinarily high LTBI prevalence among Malaysian prisoners, but provides insight into contributing factors. For example, over half of the participants in this survey were PWIDs. PWIDs represent a high-risk group for TB infection and disease progression [29] primarily due to the drug use environment itself, social and medical comorbidities and the low socioeconomic status of this population [30]. The risk is particularly high among HIV-infected PWIDs [31]. A high LTBI prevalence (ranging from 10%-59%) among PWIDs globally was recently reviewed [29] and PWIDs were concentrated among prisoners.

Prisons often lack adequate ventilation, nutrition and health services and congregate settings create an ideal environment to facilitate TB transmission to other inmates [6]. This is particularly true in settings without routine TB screening upon prison entry and thereafter. In a recent review of global screening practices in prisons, TB prevalence was found to be significantly higher in prisons without routine TB screening compared to prisons with regular screening practices (median TB prevalence of 2,227 and 343.5 cases per 100,000 population, respectively; p = 0.0059) [32]. This is in part due to lack of early detection and continued transmission to other inmates. Recently, an intensified TB case finding reported an astoundingly high prevalence (12.0%) of undiagnosed active TB disease among HIV-infected prisoners in Malaysia [33], which further supports the assumption that on-going TB transmission occurs inside Malaysian prisons and thereby contributes to the high prevalence of LTBI in this sample [5]. In the current study, the majority of subjects (82.5%) had been incarcerated at least once before and increased frequency of incarcerations was independently associated with TST positivity in this sample (AOR = 1.22 for every one previous incarceration, p = 0.01). Thus, incarceration itself contributes to increased TB acquisition.

Despite some concerns that BCG vaccination after infancy contributes to false TST reactivity [34], no association was found in this sample. The lack of association between BCG and TST positivity was confirmed among 263 health care workers (HCW) in a tertiary referral hospital in Malaysia [35]. Currently, the US Centers for Disease Control and Prevention (CDC) recommends interpretation of TST reaction regardless of the BCG vaccination history since BCG immunogenicity wanes after a few years [17].

This study corroborates earlier reports that the immunosuppressive effect of HIV infection itself impairs TST reactivity and may contribute to cutaneous anergy and potentially reduces its ability to detect LTBI [36,37]; this may be particularly true since almost half (45.6%) of the HIV-infected prisoners in this sample had a CD4 ≤350 cells/μL. Among PWIDs in the U.S., Graham et al. reported that having HIV infection is associated with lower TST positivity compared to HIV-uninfected patient (13.8% versus 25.5%) even when using the lower TST positivity cut-off of 5 mm, especially as CD4 counts decrease [36]. Nonetheless, anergic HIV-infected individuals remain at high risk of TB reactivation [38] and this forms the basis for the WHO recent recommendations to prescribe isoniazid preventive therapy (IPT) to all people living with HIV/AIDS (PLWHA), regardless of TST reactivity [39].

TB is recognized as the most common single cause of morbidity and mortality among HIV-infected PWIDs [40]. To properly control TB among PLWHA, WHO recommends the implementation of the "Three Is": infection control (IC); intensified case finding (ICF) and IPT, together with scaling up of ART. Given the difference in setting dynamics, the guidance recommends development of separate policies for implementing the "Three Is" in congregate settings [41]. Despite the particularly important role of IC measures in preventing TB transmission to other inmates and prison staff, most congregate settings in LMICs lack these measures [42,43]. Due to failure of current TB control strategies that mostly rely on passive case detection, ICF need to be integrated in TB control programs, particularly in correctional systems, where TB transmission is intense [44]. The lack of laboratory support and rapid point-of-care diagnostic tools complicates the feasibility of routine TB screening and implementation of ICF in prisons [32,43]. The new real-time PCR technology (GeneXpert MTB/RIF) offers a promising rapid and accurate diagnostic tool for detection of active TB disease and rifampicin resistance [45], but limited by cost, especially with the reduced diagnostic accuracy of a single specimen analysis in ICF surveys among PLWHA [33,46]. Though IPT for at least 6 months is an effective and inexpensive preventive tool, irrespective of the HIV status [47,48], the intervention needs to be thoroughly examined in correctional settings, especially with the additional barriers of limited access to diagnostic tools to exclude active TB disease, poor adherence rates post-release due to short incarceration periods, and high prevalence of co-morbidities (including HIV and hepatitis C virus infections) [7,28,49]. A recent systematic review showed a paucity in published reports on IPT use in correctional settings and the majority of reviewed studies were conducted in short-term detention centers and high-income, low TB-burden settings [7]. A shorter once-weekly isoniazid-rifapentine course for 3 months had a similar efficacy as IPT among predominantly HIV-uninfected persons in community settings [50] and warrants further investigation for treating LTBI in short-term detention centers and in patients co-infected with hepatitis C virus (HCV) and/or HIV. Moreover, the durability of this relatively short-duration treatment approach in congregate settings that facilitate TB transmission requires further exploration. A community-wide IPT implementation failed to prevent TB among gold miners in South Africa and the risk of TB started to increase shortly after the end of 9 months of IPT regimen [51], and has contributed in part to WHO’s recommendation for lifelong (or 36 months) IPT course for HIV-infected persons in high TB transmission areas [39].

In LMICs like Malaysia, the detrimental convergence of TB, HIV and substance abuse epidemics, particularly in correctional facilities, necessitates the establishment of an integrated control program targeting these co-morbidities [52]. Policy guidelines [52] and WHO recommends a "one-stop shopping" model to be instituted in similar settings where health services to HIV, TB, viral hepatitis and drug use treatment are co-located to improve access to health care, adherence to related medications and control and management of related co-morbidities [53]. The implementation of these recommendations remains minimal in countries where these measures are needed most.

Finally, finding alternatives to incarceration, particularly for PWID in countries that criminalize drug possession, may reduce TB burden in correctional settings through reductions in overcrowding of individuals at high risk for TB, a common phenomenon in LMICs prisons [54]. These measures may include drug courts, reduced bail payments and increased probation capacity [55].

Though the study is limited by the lack of a comparative TST survey among the Malaysian general population, the prevalence of TST positivity in this study is higher than the estimated overall LTBI prevalence (36%) in the Western Pacific region [56]. A TST survey among another high-risk group in Malaysia reported a reactive TST prevalence of 52% among predominantly young female health care workers [35]. Arguably, however, an older and predominantly male group may have higher prevalence of LTBI in an intermediate TB burden country, but the prevalence of a reactive TST was uniformly high among all screened age groups (Figure  2). Additionally, 1976 estimates of the annual risk of TB infection (ARI) in the general Malaysian population was low (0.4%) [57], which if accurate, would argue that LTBI in the community is lower than the high prevalence reported in our study.

thumbnailFigure 2. Tuberculin reactivity among different age groups.

Though the study conformed to the international guidelines of TB screening in correctional settings [6], the lack of TB diagnostic tools inside the prison and difficulties facing the referral system limited us from further assessment of active TB disease among subjects with high TST induration size, particularly among asymptomatic HIV-infected participants and should be the cornerstone of future TB screening programs.

Conclusions

The prevalence of LTBI from the largest Malaysian prison is extraordinarily high and suggests that repeated incarcerations, particularly as a failed effort to detain PWID rather than provide rehabilitation in community settings, contribute considerably to LTBI. Findings from this study suggest the need to consider alternative approaches to incarceration in general [58] that reduce placing individuals at high risk for TB in congregate settings, but to implement an integrated TB control program that simultaneously actively screens for and treats TB, HIV and substance abuse. This should also include implementation of infection control measures, intensified TB case finding by screening upon arrival and TB preventive therapy with isoniazid or short-term preventive therapy along with evidence-based treatments for HIV and opioid dependence [40]. Further research studies are urgently needed to investigate the impact of various TB preventive measures in correctional settings.

Abbreviations

ARI: Annual risk of infection; ART: Antiretroviral therapy; AOR: Adjusted odd ratio; BCG: Bacille Calmette-Guerin; CDC: US Centers for Disease Control and Prevention; HIV: Human immunodeficiency virus; HCV: Hepatitis C virus; HCW: Health care worker; IC: Infection control; ICF: Intensified case finding; IPT: Isoniazid preventive therapy; IQR: Interquartile range; LMIC: Low/middle-income countries; LTBI: Latent TB infection; PLWHA: People living with HIV/AIDS; PWID: People who inject drugs; TB: Tuberculosis; TST: Tuberculin skin test; SD: Standard deviation; WHO: World Health Organization.

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

HAAA and FLA conceptualization and designing the study; HAAA acquisition, analysis and interpretation of data; HAAA drafting the manuscript; and AK and FLA critical revision and final approval for publication. All authors read and approved the final manuscript.

Acknowledgements

The authors would like to thank the Malaysian Prison Department for allowing us to use their facilities to conduct the survey. We extend our appreciation to prisoners who agreed to participate in the survey.

This research was funded by the University of Malaya (Grant RG052 and High Impact Research Grant HIRGA E000001-20001) for HAAA and AK and the US National Institute on Drug Abuse for research (R01 DA025943, FLA) and career development (K24 DA017072, FLA).

References

  1. Basu S, Stuckler D, McKee M: Addressing institutional amplifiers in the dynamics and control of tuberculosis epidemics.

    Am J Trop Med Hyg 2011, 84(1):30-37. PubMed Abstract | Publisher Full Text | PubMed Central Full Text OpenURL

  2. Valway SE, Richards SB, Kovacovich J, Greifinger RB, Crawford JT, Dooley SW: Outbreak of multi-drug-resistant tuberculosis in a New York State prison, 1991.

    Am J Epidemiol 1994, 140(2):113-122. PubMed Abstract | Publisher Full Text OpenURL

  3. Fazel S, Baillargeon J: The health of prisoners.

    Lancet 2011, 377(9769):956-965. PubMed Abstract | Publisher Full Text OpenURL

  4. Coninx R, Maher D, Reyes H, Grzemska M: Tuberculosis in prisons in countries with high prevalence.

    BMJ 2000, 320(7232):440-442. PubMed Abstract | Publisher Full Text | PubMed Central Full Text OpenURL

  5. Johnstone-Robertson S, Lawn SD, Welte A, Bekker LG, Wood R: Tuberculosis in a South African prison - a transmission modelling analysis.

    S Afr Med J 2011, 101(11):809-813. PubMed Abstract OpenURL

  6. World Health Organisation (WHO): Tuberculosis Control in Prisons: A Manual for Programme Managers. Geneva: WHO; 2000. OpenURL

  7. Al-Darraji HAA, Kamarulzaman A, Altice FL: Isoniazid preventive therapy in correctional facilities: a systematic review [Review article].

    Int J Tuberc Lung Dis 2012, 16(7):871-879. PubMed Abstract | Publisher Full Text OpenURL

  8. Stuckler D, Basu S, McKee M, King L: Mass incarceration can explain population increases in TB and multidrug-resistant TB in European and central Asian countries.

    Proc Natl Acad Sci USA 2008, 105(36):13280-13285. PubMed Abstract | Publisher Full Text | PubMed Central Full Text OpenURL

  9. Vagenas P, Azbel L, Polonsky M, Kerimi N, Mamyrov M, Dvoryak S, Altice FL: A review of medical and substance use co-morbidities in central asian prisons: implications for HIV prevention and treatment.

    Drug Alcohol Depend 2013, 132(Suppl 1):S25-S31. PubMed Abstract | Publisher Full Text OpenURL

  10. Baussano I, Williams BG, Nunn P, Beggiato M, Fedeli U, Scano F: Tuberculosis incidence in prisons: a systematic review.

    PLoS Med 2010, 7(12):e1000381. PubMed Abstract | Publisher Full Text | PubMed Central Full Text OpenURL

  11. World Health Organization (WHO): Global Tuberculosis Control: WHO Report 2011. Geneva: WHO Press; 2011. OpenURL

  12. Choi P, Kavasery R, Desai MM, Govindasamy S, Kamarulzaman A, Altice FL: Prevalence and correlates of community re-entry challenges faced by HIV-infected male prisoners in Malaysia.

    Int J STD AIDS 2010, 21(6):416-423. PubMed Abstract | Publisher Full Text | PubMed Central Full Text OpenURL

  13. Zahari MM, Hwan Bae W, Zainal NZ, Habil H, Kamarulzaman A, Altice FL: Psychiatric and substance abuse comorbidity among HIV seropositive and HIV seronegative prisoners in Malaysia.

    Am J Drug Alcohol Abuse 2010, 36(1):31-38. PubMed Abstract | Publisher Full Text OpenURL

  14. World Health Organization (WHO): Assessment of compulsory treatment of people who use drugs in Cambodia, China, Malaysia and Viet Nam: an application of selected human rights principles. Western Pacific Regional Office: WHO; 2009. OpenURL

  15. Fu JJ, Bazazi AR, Altice FL, Mohamed MN, Kamarulzaman A: Absence of antiretroviral therapy and other risk factors for morbidity and mortality in Malaysian compulsory drug detention and rehabilitation centers.

    PloS One 2012, 7(9):e44249. PubMed Abstract | Publisher Full Text | PubMed Central Full Text OpenURL

  16. Suruhanjaya Hak Asasi Manusia Malaysia:

    The State Of Prisons And Immigration Detention Centres In Malaysia 2007 – 2008. 2008.

    http://www.suhakam.org.my/c/document_library/get_file?p_l_id=10408&folderId=236834&name=DLFE-237802.pdf webcite

    OpenURL

  17. Center for Disease Control (CDC), Infectious Disease Society of America (IDSA), American Thoracic Society (ATS): Targeted tuberculin testing and treatment of latent tuberculosis infection. American Thoracic Society.

    MMWR Recomm Rep 2000, 49(RR-6):1-51. OpenURL

  18. Rafiza S, Rampal KG, Tahir A: Prevalence and risk factors of latent tuberculosis infection among health care workers in Malaysia.

    BMC Infect Dis 2011, 11:19. PubMed Abstract | BioMed Central Full Text | PubMed Central Full Text OpenURL

  19. Awofeso N: Prisons as social determinants of hepatitis C virus and tuberculosis infections.

    Public Health Rep 2010, 125(Suppl 4):25-33. PubMed Abstract | PubMed Central Full Text OpenURL

  20. Hussain H, Akhtar S, Nanan D: Prevalence of and risk factors associated with Mycobacterium tuberculosis infection in prisoners, North West Frontier Province, Pakistan.

    Int J Epidemiol 2003, 32(5):794-799. PubMed Abstract | Publisher Full Text OpenURL

  21. Nogueira PA, Abrahao RM, Galesi VM: Tuberculosis and latent tuberculosis in prison inmates.

    Revista de saude publica 2012, 46(1):119-127. PubMed Abstract | Publisher Full Text OpenURL

  22. Adib SM, Al-Takash H, Al-Hajj C: Tuberculosis in lebanese jails: prevalence and risk factors.

    Eur J Epidemiol 1999, 15(3):253-260. PubMed Abstract | Publisher Full Text OpenURL

  23. Chee CB, Teleman MD, Boudville IC, Wang YT: Contact screening and latent TB infection treatment in Singapore correctional facilities.

    Int J Tuberc Lung Dis 2005, 9(11):1248-1252. PubMed Abstract | Publisher Full Text OpenURL

  24. Marco A, Sole N, Orcau A, Escribano M, del Bano L, Quintero S, Cayla JA: Prevalence of latent tuberculosis infection in inmates recently incarcerated in a men’s prison in Barcelona.

    Int J Tuberc Lung Dis 2012, 16(1):60-64. PubMed Abstract | Publisher Full Text OpenURL

  25. Martin V, Guerra JM, Cayla JA, Rodriguez JC, Blanco MD, Alcoba M: Incidence of tuberculosis and the importance of treatment of latent tuberculosis infection in a Spanish prison population.

    Int J Tuberc Lung Dis 2001, 5(10):926-932. PubMed Abstract | Publisher Full Text OpenURL

  26. Ritter C, Elger BS: Prevalence of positive tuberculosis skin tests during 5 years of screening in a Swiss remand prison.

    Int J Tuberc Lung Dis 2012, 16(1):65-69. PubMed Abstract | Publisher Full Text OpenURL

  27. Carbonara S, Babudieri S, Longo B, Starnini G, Monarca R, Brunetti B, Andreoni M, Pastore G, De Marco V, Rezza G: Correlates of Mycobacterium tuberculosis infection in a prison population.

    Eur Respir J 2005, 25(6):1070-1076. PubMed Abstract | Publisher Full Text OpenURL

  28. Lobato MN, Leary LS, Simone PM: Treatment for latent TB in correctional facilities: a challenge for TB elimination.

    Am J Prev Med 2003, 24(3):249-253. PubMed Abstract | Publisher Full Text OpenURL

  29. Deiss RG, Rodwell TC, Garfein RS: Tuberculosis and illicit drug use: review and update.

    Clin Infect Dis 2009, 48(1):72-82. PubMed Abstract | Publisher Full Text | PubMed Central Full Text OpenURL

  30. Centers for Disease Control and Prevention (CDC): Guidelines for the investigation of contacts of persons with infectious tuberculosis; recommendations from the national tuberculosis controllers association and CDC.

    MMWR 2005, 54(No. RR-15):1-37. OpenURL

  31. Selwyn PA, Hartel D, Lewis VA, Schoenbaum EE, Vermund SH, Klein RS, Walker AT, Friedland GH: A prospective study of the risk of tuberculosis among intravenous drug users with human immunodeficiency virus infection.

    N Engl J Med 1989, 320(9):545-550. PubMed Abstract | Publisher Full Text OpenURL

  32. Vinkeles Melchers NV, van Elsland SL, Lange JM, Borgdorff MW, van den Hombergh J: State of affairs of tuberculosis in prison facilities: a systematic review of screening practices and recommendations for best TB control.

    PLoS One 2013, 8(1):e53644. PubMed Abstract | Publisher Full Text | PubMed Central Full Text OpenURL

  33. Al-Darraji HA, Razak HA, Ng KP, Altice FL, Kamarulzaman A: The diagnostic performance of a single GeneXpert MTB/RIF assay in an intensified tuberculosis case finding survey among HIV-infected prisoners in malaysia.

    PLoS One 2013, 8(9):e73717. PubMed Abstract | Publisher Full Text | PubMed Central Full Text OpenURL

  34. Farhat M, Greenaway C, Pai M, Menzies D: False-positive tuberculin skin tests: what is the absolute effect of BCG and non-tuberculous mycobacteria?

    Int J Tuberc Lung Dis 2006, 10(11):1192-1204. PubMed Abstract | Publisher Full Text OpenURL

  35. Tan LH, Kamarulzaman A, Liam CK, Lee TC: Tuberculin skin testing among healthcare workers in the University of Malaya Medical Centre, Kuala Lumpur, Malaysia.

    Infect Control Hosp Epidemiol 2002, 23(10):584-590. PubMed Abstract | Publisher Full Text OpenURL

  36. Graham NM, Nelson KE, Solomon L, Bonds M, Rizzo RT, Scavotto J, Astemborski J, Vlahov D: Prevalence of tuberculin positivity and skin test anergy in HIV-1-seropositive and -seronegative intravenous drug users.

    JAMA 1992, 267(3):369-373. PubMed Abstract | Publisher Full Text OpenURL

  37. Portu JJ, Aldamiz-Etxebarria M, Agud JM, Arevalo JM, Almaraz MJ, Ayensa C: Tuberculin skin testing in intravenous drug users: differences between HIV-seropositive and HIV-seronegative subjects.

    Addict Biol 2002, 7(2):235-241. PubMed Abstract | Publisher Full Text OpenURL

  38. Selwyn PA, Sckell BM, Alcabes P, Friedland GH, Klein RS, Schoenbaum EE: High risk of active tuberculosis in HIV-infected drug users with cutaneous anergy.

    JAMA 1992, 268(4):504-509. PubMed Abstract | Publisher Full Text OpenURL

  39. World Health Organization (WHO): Guidelines for intensified tuberculosis case-finding and isoniazid preventive therapy for people living with HIV in resource-constrained settings. Geneva: WHO Press; 2011. OpenURL

  40. Altice FL, Kamarulzaman A, Soriano VV, Schechter M, Friedland GH: Treatment of medical, psychiatric, and substance-use comorbidities in people infected with HIV who use drugs.

    Lancet 2010, 376(9738):367-387. PubMed Abstract | Publisher Full Text OpenURL

  41. World Health Organisation (WHO): Three I’s for HIV/TB Meeting Report. Intensified case-finding (ICF), isoniazid preventive therapy (IPT) and TB infection control (IC) for people living with HIV. Geneva: WHO; 2008. OpenURL

  42. World Health Organization (WHO): WHO policy on TB infection control in health-care facilities, congregate settings and households. Geneva: WHO Press; 2009. OpenURL

  43. O’Grady J, Hoelscher M, Atun R, Bates M, Mwaba P, Kapata N, Ferrara G, Maeurer M, Zumla A: Tuberculosis in prisons in sub-Saharan Africa–the need for improved health services, surveillance and control.

    Tuberculosis (Edinb) 2011, 91(2):173-178. PubMed Abstract | Publisher Full Text OpenURL

  44. Golub JE, Mohan CI, Comstock GW, Chaisson RE: Active case finding of tuberculosis: historical perspective and future prospects.

    Int J Tuberc Lung Dis 2005, 9(11):1183-1203. PubMed Abstract | Publisher Full Text OpenURL

  45. Boehme CC, Nabeta P, Hillemann D, Nicol MP, Shenai S, Krapp F, Allen J, Tahirli R, Blakemore R, Rustomjee R, et al.: Rapid molecular detection of tuberculosis and rifampin resistance.

    N Engl J Med 2010, 363(11):1005-1015. PubMed Abstract | Publisher Full Text | PubMed Central Full Text OpenURL

  46. Lawn SD, Brooks SV, Kranzer K, Nicol MP, Whitelaw A, Vogt M, Bekker L-G, Wood R: Screening for HIV-associated tuberculosis and rifampicin resistance before antiretroviral therapy using the Xpert MTB/RIF assay: a prospective study.

    PLoS Med 2011, 8:e1001067. PubMed Abstract | Publisher Full Text | PubMed Central Full Text OpenURL

  47. Akolo C, Adetifa I, Shepperd S, Volmink J: Treatment of latent tuberculosis infection in HIV infected persons.

    Cochrane Database Syst Rev 2010, (1):Art. No.:CD000171. OpenURL

  48. Smieja MJ, Marchetti CA, Cook DJ, Smaill FM: Isoniazid for preventing tuberculosis in non-HIV infected persons.

    Cochrane Database Syst Rev 1999, (1):Art. No. CD001363. OpenURL

  49. Getahun H, Granich R, Sculier D, Gunneberg C, Blanc L, Nunn P, Raviglione M: Implementation of isoniazid preventive therapy for people living with HIV worldwide: barriers and solutions.

    AIDS 2010, 24(Suppl 5):S57-S65. PubMed Abstract | Publisher Full Text OpenURL

  50. Sterling TR, Villarino ME, Borisov AS, Shang N, Gordin F, Bliven-Sizemore E, Hackman J, Hamilton CD, Menzies D, Kerrigan A, et al.: Three months of rifapentine and isoniazid for latent tuberculosis infection.

    N Engl J Med 2011, 365(23):2155-2166. PubMed Abstract | Publisher Full Text OpenURL

  51. Churchyard G, Fielding K, Lewis J: Community-wide Isoniazid Preventive Therapy Does Not Improve TB Control among Gold Miners: The Thibela TB Study, South Africa (Abstract 150aLB). In 19th Conference on Retroviruses and Opportunistic Infections (CROI 2012). Seattle, Washington; 2012. OpenURL

  52. Sylla L, Bruce RD, Kamarulzaman A, Altice FL: Integration and co-location of HIV/AIDS, tuberculosis and drug treatment services.

    Int J Drug Policy 2007, 18(4):306-312. PubMed Abstract | Publisher Full Text | PubMed Central Full Text OpenURL

  53. World Health Organization (WHO): Policy Guidelines For Collaborative TB And HIV Services For Injecting And Other Drug Users: An Integrated Approach. Geneva: WHO Press; 2008. OpenURL

  54. Jittimanee SX, Ngamtrairai N, White MC, Jittimanee S: A prevalence survey for smear-positive tuberculosis in Thai prisons.

    Int J Tuberc Lung Dis 2007, 11(5):556-561. PubMed Abstract | Publisher Full Text OpenURL

  55. Reid SE, Topp SM, Turnbull ER, Hatwiinda S, Harris JB, Maggard KR, Roberts ST, Kruuner A, Morse JC, Kapata N, et al.: Tuberculosis and HIV control in sub-Saharan African prisons: "thinking outside the prison cell".

    J Infect Dis 2012, 205(Suppl 2):S265-273. PubMed Abstract | Publisher Full Text OpenURL

  56. Dye C, Scheele S, Dolin P, Pathania V, Raviglione MC: Consensus statement. Global burden of tuberculosis: estimated incidence, prevalence, and mortality by country. WHO global surveillance and monitoring project.

    JAMA 1999, 282(7):677-686. PubMed Abstract | Publisher Full Text OpenURL

  57. Cauthen GM, Pio A, ten Dam HG: Annual Risk of Tuberculous Infection. Geneva: WHO; 1988. OpenURL

  58. Maru DS, Basu S, Altice FL: HIV control efforts should directly address incarceration.

    Lancet Infect Dis 2007, 7(9):568-569. PubMed Abstract | Publisher Full Text OpenURL

Pre-publication history

The pre-publication history for this paper can be accessed here:

http://www.biomedcentral.com/1471-2458/14/22/prepub