Open Access Research article

Prevalence of congenital heart defect in Guangdong province, 2008-2012

Li Wu1, Bing Li1, Jianhong Xia1, Cunwei Ji1, Zhijiang Liang1, Yuanzhu Ma1, Shiyun Li1, Yuntao Wu1, Youjie Wang2 and Qingguo Zhao1*

Author Affiliations

1 Guangdong Women and Children Hospital, Guangzhou, China

2 Department of Maternal and Child health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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BMC Public Health 2014, 14:152  doi:10.1186/1471-2458-14-152

Published: 11 February 2014



Congenital heart defect (CHD) is the most common major malformations in infants. Little is known about the main epidemiologic characteristics of CHD prevalence in Guangdong province, China. Our study was undertaken to investigate the time trends in the prevalence of CHD in Guangdong province from 2008 to 2012.


Data were retrieved from the Guangdong Hospital-Based Birth Defects Monitoring System during 2008–2012. All infants more than 28 weeks of gestation and infants up to 7 days of age in monitoring hospitals were monitored. We used prevalence rate to describe the difference in prevalence of CHD between rural and urban areas. Odds ratio (OR) and 95% confidence interval (CI) for CHD were calculated for the rural and urban areas. The CHD rate was calculated on the basis of birth defects per 10,000 births.


A total of 1005052 births were reported to the Birth Defects Monitoring Network of Guangdong Province, of which 5268 cases were diagnosed as CHD. The overall prevalence of CHD was 52.41 per 10 000 births (95% CI: 51.00 ~ 53.83) in provincial-wide, 66.08 per 10 000 births (95% CI: 63.77 ~ 68.39) in urban areas, and 40.23 per 10 000 births (95% CI: 38.52 ~ 41.93) in rural areas. The prevalence of CHD increased with maternal age both in urban areas (P < 0.01) and in rural areas (P < 0.01).


The increasing trends of CHD prevalence suggest that maternal age and the improvement of diagnosis ability might play a critical role.

Birth defects; Congenital heart defect; Prevalence