Table 5

Quality assessment of studies on commercial/specialized ingredients versus home-available ingredients

QUALITY ASSESSMENT

SUMMARY OF FINDINGS


Number of studies

Diarrhea mode

Design

Limitations

Consistency

Generalizability to population of interest

Overall quality of evidence

Number of events in intervention group

Number of events in control group

Effect size (95% CI)


OUTCOME: DURATION OF DIARRHEA

Standardized Mean Difference


3

Acute

RCT

Study quality ranges from moderate to high

Consistent (I2= 0%)

Infants and young children (≤24m) with acute diarrhea, without severe malnutrition, in LMICs

Moderate

-

-

-0.13 [-0.36, 0.09]

3

Persistent

RCT

Studies of moderate quality

Consistent (I2= 0%)

Malnourished infants and young children (≤36m) with persistent diarrhea in LMICs

Moderate

-

-

-0.03 [-0.37, 0.32]


OUTCOME: STOOL OUTPUT

Standardized Mean Difference


4

Acute

RCT

Study quality ranges from moderate to high

Consistent (I2= 0%)

Infants and young children (≤36m) with acute diarrhea, without severe malnutrition, in LMICs

Moderate

-

-

0.15 [-0.06, 0.36]

3

Persistent

RCT

Studies of moderate quality

Consistent (I2= 25%)

Malnourished infants and young children (≤36m) with persistent diarrhea in LMICs

Moderate

-

-

0.16 [-0.23, 0.54]


OUTCOME: WEIGHT GAIN

Standardized Mean Difference


5

Acute

RCT

Study quality ranges from moderate to high

Heterogeneous (I2= 58%)

Infants and young children (≤36m) with acute diarrhea, without severe malnutrition, in LMICs

Moderate

-

-

-0.09 [-0.40, 0.23]

4

Persistent

RCT

Study quality ranges from low to moderate

Heterogeneous (I2= 88%)

Malnourished infants and young children (≤36m) with persistent diarrhea in LMICs

Low

-

-

0.04 (-0.90, 0.97)


OUTCOME: TREATMENT FAILURE

Risk Ratio


8

Acute

RCT

Study quality ranges from moderate to high

Heterogeneous (I2= 49%)

Infants and young children (≤36m) with acute diarrhea, without severe malnutrition, in LMICs

Moderate

34

25

0.82 [0.37, 1.79]

5

Persistent

RCT

Study quality ranges from low to high; nutritional status ranges from non-malnourished to severely malnourished

Heterogeneous (I2= 67%)

Infants and young children (≤36m) with persistent diarrhea in LMICs

Low

21

22

0.55 [0.17, 1.74]


Gaffey et al. BMC Public Health 2013 13(Suppl 3):S17   doi:10.1186/1471-2458-13-S3-S17

Open Data