Table 3

Quality assessment of trials of antibiotics for the treatment of cryptosporidium

Quality Assessment

Summary of Findings


Directness

No of events


No of studies

Design

Limitations

Consistency

Generalizability to population of interest

Generalizability to intervention of interest

Intervention

Control

Relative Risk (95%CI)


Mortality – All Cause (Antibiotics vs. Placebo): Low Outcome Quality


02[30,32]

RCT

One study used nitazoxanide while one used spiramycin

All studies suggested benefit

All studies were conducted in developing country

Hospital based

1

6

0.24 [0.04, 1.45]a


Clinical Failure (Antibiotics vs. Placebo): Moderate Outcome Quality


02[30,31]

RCT

Both used nitazoxanide and suggested benefit

All studies were conducted in developing country

Hospital based

14

32

0.48 (0.30, 0.75)a


Parasitological Failure (Antibiotics vs. Placebo): Moderate Outcome Quality


03[30-32]

RCT

Two studies used nitazoxanide While one used spiramycin

All studies suggest benefit

All studies were conducted in developing country

Hospital based

31

51

0.62 [0.46, 0.83]a


a= Fixed Effect Model

b= Random Effect Model

Das et al. BMC Public Health 2013 13(Suppl 3):S10   doi:10.1186/1471-2458-13-S3-S10

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