Table 2

User-modifiable disease-specific parameters
Parameter type Parameter Definition
Natural history parameters Days latent Discrete cdf for number of days between becoming exposed and becoming infectious
Symptomatic rate The probability of an infected person becoming symptomatic
Days asymptomatic Discrete cdf for number of days the agent is infectious but asymptomatic
Days symptomatic Discrete cdf for number of days the agent is infectious and symptomatic
Immunity loss rate Rate at which a person loses immunity after recovering from infection
Mortality rate The probability of an infected person dying
Contact parameters Probability of staying home The baseline probability that an agent stays home if the agent experiences a symptomatic infection.
Household contact rates The expected number of potentially infective daily contacts between an infectious agent and a susceptible agent in a household. All contact rates are positive real numbers.
Neighborhood contact rates The expected number of potentially infective daily contacts between an infectious agent and a susceptible agent in a neighborhood
School contact rates The expected number of potentially infective daily contacts between an infectious agent and a susceptible agent in a school
Workplace contact rates The expected number of potentially infective daily contacts between an infectious agent and a susceptible agent in a workplace.
Transmission parameters Transmissibility The transmissibility of disease relative to an arbitrary baseline set by calibration
Asymptomatic infectivity Multiplier for how infective an asymptomatic infected agent is, relative to an symptomatic agent
Household transmission probability A table of probabilities that a potentially infective contact between an infectious agent and a symptomatic agent in the same household actually results in an infection, given the age of the potential infector/infectee pair
Neighborhood transmission probability A table of probabilities that a potentially infective contact between an infectious agent and a symptomatic agent occurring in a neighborhood actually results in an infection, given the age of the potential infector/infectee pair
School transmission probability A table of probabilities that a potentially infective contact between an infectious agent and a symptomatic agent occurring in a school actually results in an infection, given the age of the potential infector/infectee pair
Workplace transmission probability A table of probabilities that a potentially infective contact between an infectious agent and a symptomatic agent occurring in a workplace actually results in an infection, given the age of the potential infector/infectee pair

FRED includes natural history and transmission parameters for pandemic influenza as used in previous models [5-12]. Contact parameters were calibrated for the FRED synthetic population using the methods described in [12]. For more details about these and other user-settable parameters, please see the FRED User Guide.

Grefenstette et al.

Grefenstette et al. BMC Public Health 2013 13:940   doi:10.1186/1471-2458-13-940

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