## Table 2 |
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User-modifiable disease-specific parameters |
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Parameter type |
Parameter |
Definition |

Natural history parameters |
Days latent | Discrete cdf for number of days between becoming exposed and becoming infectious |

Symptomatic rate | The probability of an infected person becoming symptomatic | |

Days asymptomatic | Discrete cdf for number of days the agent is infectious but asymptomatic | |

Days symptomatic | Discrete cdf for number of days the agent is infectious and symptomatic | |

Immunity loss rate | Rate at which a person loses immunity after recovering from infection | |

Mortality rate | The probability of an infected person dying | |

Contact parameters |
Probability of staying home | The baseline probability that an agent stays home if the agent experiences a symptomatic infection. |

Household contact rates | The expected number of potentially infective daily contacts between an infectious agent and a susceptible agent in a household. All contact rates are positive real numbers. | |

Neighborhood contact rates | The expected number of potentially infective daily contacts between an infectious agent and a susceptible agent in a neighborhood | |

School contact rates | The expected number of potentially infective daily contacts between an infectious agent and a susceptible agent in a school | |

Workplace contact rates | The expected number of potentially infective daily contacts between an infectious agent and a susceptible agent in a workplace. | |

Transmission parameters |
Transmissibility | The transmissibility of disease relative to an arbitrary baseline set by calibration |

Asymptomatic infectivity | Multiplier for how infective an asymptomatic infected agent is, relative to an symptomatic agent | |

Household transmission probability | A table of probabilities that a potentially infective contact between an infectious agent and a symptomatic agent in the same household actually results in an infection, given the age of the potential infector/infectee pair | |

Neighborhood transmission probability | A table of probabilities that a potentially infective contact between an infectious agent and a symptomatic agent occurring in a neighborhood actually results in an infection, given the age of the potential infector/infectee pair | |

School transmission probability | A table of probabilities that a potentially infective contact between an infectious agent and a symptomatic agent occurring in a school actually results in an infection, given the age of the potential infector/infectee pair | |

Workplace transmission probability | A table of probabilities that a potentially infective contact between an infectious agent and a symptomatic agent occurring in a workplace actually results in an infection, given the age of the potential infector/infectee pair |

FRED includes natural history and transmission parameters for pandemic influenza as used in previous models [5-12]. Contact parameters were calibrated for the FRED synthetic population using the methods described in [12]. For more details about these and other user-settable parameters, please see the FRED User Guide.

Grefenstette * et al.*

Grefenstette * et al.* *BMC Public Health* 2013 **13**:940 doi:10.1186/1471-2458-13-940