|Cost-benefit analyses of vaccination programs in the general population|
|First author [Reference]||Bjerregaard []||Pelletier []||Elo []||Berger []|
|WB income group||High||High||High||High|
|Comparators||1. Vaccinate 15-month and 12-yr-olds||1. 1-dose child vaccination campaign||1. Vaccinate 13-yr-olds & post-partum women||1. Vaccinate children from 1 – 12 years|
|2. Vaccinate only 15-month-olds||2. 2-dose child vaccination campaign||2. Vaccinate 13-yr-olds & 1-yr-olds||2. Vaccinate only 12-yr-olds (routine)|
|3. 1-dose child vaccination||3. Vaccinate only 1-yr-olds over 20 years|
|4. 2-dose child vaccination|
|Cost components measured||OP visits; prescriptions; hospitalizations; vaccines||OP visits; hospitalizations; laboratory tests; nursing home care; special education; indirect costs (lost productivity for illness, disability and premature death)||Fetal loss; fetal damage; annual costs; long-term costs||Vaccine; vaccination side effects; serology; OP visits; hospitalizations; hearing aids; mothers’ work loss;|
|Method of cost estimation||Micro-costing||Micro-costing; Lifetime earnings (for indirect costs)||Top-down costing based on Delphi panel||Micro-costing|
|Method of benefits estimation||Averted costs||Averted costs||Averted costs||Averted costs|
|Time period for costs and benefits||20 years||Lifetime||30 years||13 years|
|Discounting (Rate)||NR||Yes (5%)||Yes (6%)||Yes (5 and 10%)|
|Results—Benefit-cost ratio||1. 3||1. 2.6||1. 10||1. 1.1|
|2. 2||2. 2.9||2. 3||2. 1.8|
|3. 3.6||3. 6|
|Stated conclusion||Vaccinating both age groups is preferable||The benefits of a second dose outweigh the costs||Vaccinating 13-yr-old girls and postpartum women was preferable||Vaccinating infants and adolescent girls is preferable|
*Not explicitly reported but inferred.
WB, World Bank; NR, Not Reported; NA, Not Applicable; OP, Out Patient; CDC, US Centers for Disease Control and Prevention; LCDC, Canada Laboratory Center for Disease Control.
Babigumira et al.
Babigumira et al. BMC Public Health 2013 13:406 doi:10.1186/1471-2458-13-406