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Open Access Highly Accessed Research article

The spatial epidemiology of tuberculosis in Linyi City, China, 2005–2010

Tao Wang12, Fuzhong Xue1, Yongjin Chen3, Yunbo Ma3 and Yanxun Liu1*

Author Affiliations

1 Department of Epidemiology and Health Statistics, Shandong University, Jinan, 250012, People’s Republic of China

2 Zibo Municipal Center for Disease Control and Prevention, Zibo, 255026, People’s Republic of China

3 Linyi People’s Hospital, Linyi, 276000, People’s Republic of China

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BMC Public Health 2012, 12:885  doi:10.1186/1471-2458-12-885

Published: 19 October 2012

Abstract

Background

Tuberculosis (TB) remains a major public health burden in many developing countries. China alone accounted for an estimated 12% of all incident TB cases worldwide in 2010. Several studies showed that the spatial distribution of TB was nonrandom and clustered. Thus, a spatial analysis was conducted with the aim to explore the spatial epidemiology of TB in Linyi City, which can provide guidance for formulating regional prevention and control strategies.

Methods

The study was based on the reported cases of TB, between 2005 and 2010. 35,308 TB cases were geo-coded at the town level (n = 180). The spatial empirical Bayes smoothing, spatial autocorrelation and space-time scan statistic were used in this analysis.

Results

Spatial distribution of TB in Linyi City from 2005 to 2010 was mapped at town level in the aspects of crude incidence, excess hazard and spatial smoothed incidence. The spatial distribution of TB was nonrandom and clustered with the significant Moran’s I for each year. Local Gi* detected five significant spatial clusters for high incidence of TB. The space-time analysis identified one most likely cluster and nine secondary clusters for high incidence of TB.

Conclusions

There is evidence for the existence of statistically significant TB clusters in Linyi City, China. The result of this study may assist health departments to develop a better preventive strategy and increase the public health intervention’s effectiveness.