Email updates

Keep up to date with the latest news and content from BMC Public Health and BioMed Central.

Open Access Highly Accessed Research article

Clinical, epidemiological, and spatial characteristics of Vibrio parahaemolyticus diarrhea and cholera in the urban slums of Kolkata, India

Suman Kanungo1, Dipika Sur1, Mohammad Ali2*, Young Ae You2, Debottam Pal1, Byomkesh Manna1, Swapan K Niyogi1, Banwarilal Sarkar1, Sujit K Bhattacharya3, John D Clemens24 and G Balakrish Nair1

Author Affiliations

1 National Institute of Cholera and Enteric Diseases, Kolkata, India

2 International Vaccine Institute, Seoul, Republic of Korea

3 Society for Applied Studies, Salt Lake City, Kolkata, India

4 UCLA School of Public Health, Los Angeles, USA

For all author emails, please log on.

BMC Public Health 2012, 12:830  doi:10.1186/1471-2458-12-830

Published: 28 September 2012

Abstract

Background

There is not much information on the differences in clinical, epidemiological and spatial characteristics of diarrhea due to V. cholerae and V. parahaemolyticus from non-coastal areas. We investigated the differences in clinical, epidemiological and spatial characteristics of the two Vibrio species in the urban slums of Kolkata, India.

Methods

The data of a cluster randomized cholera vaccine trial were used. We restricted the analysis to clusters assigned to placebo. Survival analysis of the time to the first episode was used to analyze risk factors for V. parahaemolyticus diarrhea or cholera. A spatial scan test was used to identify high risk areas for cholera and for V. parahaemolyticus diarrhea.

Results

In total, 54,519 people from the placebo clusters were assembled. The incidence of cholera (1.30/1000/year) was significantly higher than that of V. parahaemolyticus diarrhea (0.63/1000/year). Cholera incidence was inversely related to age, whereas the risk of V. parahaemolyticus diarrhea was age-independent. The seasonality of diarrhea due to the two Vibrio species was similar. Cholera was distinguished by a higher frequency of severe dehydration, and V. parahaemolyticus diarrhea was by abdominal pain. Hindus and those who live in household not using boiled or treated water were more likely to have V. parahaemolyticus diarrhea. Young age, low socioeconomic status, and living closer to a project healthcare facility were associated with an increased risk for cholera. The high risk area for cholera differed from the high risk area for V. parahaemolyticus diarrhea.

Conclusion

We report coexistence of the two vibrios in the slums of Kolkata. The two etiologies of diarrhea had a similar seasonality but had distinguishing clinical features. The risk factors and the high risk areas for the two diseases differ from one another suggesting different modes of transmission of these two pathogens.

Keywords:
Vibrio parahaemolyticus; Vibrio cholerae; Cholera; Kolkata