Table 1

Baseline Characteristics of 27,204 cohort members according to their Pneumococcal vaccination status before the study started

Characteristic

Unvaccinateda

(n = 18,223)

Vaccinated

(n = 8,981)

p valueb

Total

N = 27,204


No. (%)


Age group, yrsc

60-69

8522 (46.8)

3879 (43.2)

< 0.001

12401 (45.6)

70-79

5833 (32.0)

3451 (38.4)

9284 (34.1)

≥ 80

3868 (21.2)

1651 (18.4)

5519 (20.3)


Sex, Male

8074 (44.3)

4063 (45.2)

0.145

12137 (44.6)


No. of outpatient visits during previous 12 monthsd

[0-2]

4886 (26.8)

1168 (13)

< 0.001

6054(22.3)

[3-5]

4183 (23.0)

2207 (24.6)

6390(23.5)

[6-9]

4338 (23.8)

2569 (28.6)

6907(25.4)

≥10

4816 (26.4)

3037 (33.8)

7853(28.9)


Influenza vaccination in previous Autumn

6997 (38.4)

7371 (82.1)

< 0.001

14368 (52.8)


History of coronary artery disease

1122 (6.2)

611 (6.8)

0.040

1733 (6.4)


History of stroke

808 (4.4)

486 (5.4)

< 0.001

1294 (4.8)


Chronic pulmonary disease

1421 (7.8)

742 (8.3)

0.183

2163 (8.0)


Chronic heart diseasee

2084 (11.4)

1324 (14.7)

< 0.001

3408 (12.5)


Chronic liver disease

383 (2.1)

239 (2.7)

0.004

622 (2.3)


Chronic nephropathy

44 (2.4)

214 (2.4)

0.786

658 (2.4)


Diabetes mellitus

3713 (20.4)

2192 (24.4)

< 0.001

5905 (21.7)


Hypertension

9245 (50.7)

5304 (59.1)

< 0.001

14549 (53.5)


Hypercholesterolemia

6351 (34.9)

3611 (40.2)

< 0.001

9962 (36.6)


Obesity (BMI > 30)

5089 (27.9)

3150 (35.1)

< 0.001

8239 (30.3)


Smoking status


Non-smoker

12855 (70.5)

5826 (64.9)

< 0.001

18681(68.7)


Quit

3479 (19.1)

2248 (25.0)

5727(21.1)


Current

1889 (10,4)

907 (10.1)

2796(10.3)


Alcoholism

655 (3.6)

340 (3.8)

0.429

995 (3.7)


Cancer

1297 (7.1)

703 (7.8)

0.035

2000 (7.4)


Immunosuppressive medication

772 (4.2)

425 (4.7)

0.061

1197 (4.4)


Immunocompromisef

1921 (10.5)

1005 (11.2)

0.104

2926 (10.8)


Dementia

535 (2.9)

266 (3.0)

0.905

801 (2.9)


Nursing-home residence

265 (1.5)

110 (1.2)

0.127

375 (1.4)


a An amount of 6,179 individuals were classified as non-immunized because they had received the PPV23 more than 60 months before study start.

b p values were calculated with chi-square test.

c The mean ages of the unvaccinated and vaccinated subjects were 71.5 years (Standard Deviation, SD: 8.9) and 72.0 years (SD: 7.8) respectively. Mean age of overall study subjects was 71.7 years (SD: 8.6).

d The mean number of outpatient visits during previous 12 months were 7.1 (SD: 6.7) in unvaccinated and 8.4 (SD: 6.3) in vaccinated subjects. Mean number of visits among the overall study population was 7.5 (SD: 6.6).

e It includes congestive heart failure, hypertensive heart disease, cardiomyopathy, valvulopathy, cardiac dilatation or ventricular hypertrophy.

f Immunocompromise was a composite variable defined by the presence of any one of the following: cancer (solid organ or haematological neoplasia), chronic severe nephropathy (nephrotic syndrome, renal failure, dialysis or transplantation), anatomical or functional asplenia, immunodeficiency (including AIDS), and long-term corticosteroid therapy (20 mg/day of prednisone) or another immunosuppressive medication.

Vila-Corcoles et al. BMC Public Health 2012 12:222   doi:10.1186/1471-2458-12-222

Open Data