Table 1 |
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Baseline Characteristics of 27,204 cohort members according to their Pneumococcal vaccination status before the study started |
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|
Characteristic |
Unvaccinateda (n = 18,223) |
Vaccinated (n = 8,981) |
p valueb |
Total N = 27,204 |
|
|
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|
No. (%) |
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|
|
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|
Age group, yrsc |
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|
60-69 |
8522 (46.8) |
3879 (43.2) |
< 0.001 |
12401 (45.6) |
|
70-79 |
5833 (32.0) |
3451 (38.4) |
9284 (34.1) |
|
|
≥ 80 |
3868 (21.2) |
1651 (18.4) |
5519 (20.3) |
|
|
|
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|
Sex, Male |
8074 (44.3) |
4063 (45.2) |
0.145 |
12137 (44.6) |
|
|
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|
No. of outpatient visits during previous 12 monthsd |
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|
[0-2] |
4886 (26.8) |
1168 (13) |
< 0.001 |
6054(22.3) |
|
[3-5] |
4183 (23.0) |
2207 (24.6) |
6390(23.5) |
|
|
[6-9] |
4338 (23.8) |
2569 (28.6) |
6907(25.4) |
|
|
≥10 |
4816 (26.4) |
3037 (33.8) |
7853(28.9) |
|
|
|
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|
Influenza vaccination in previous Autumn |
6997 (38.4) |
7371 (82.1) |
< 0.001 |
14368 (52.8) |
|
|
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|
History of coronary artery disease |
1122 (6.2) |
611 (6.8) |
0.040 |
1733 (6.4) |
|
|
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|
History of stroke |
808 (4.4) |
486 (5.4) |
< 0.001 |
1294 (4.8) |
|
|
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|
Chronic pulmonary disease |
1421 (7.8) |
742 (8.3) |
0.183 |
2163 (8.0) |
|
|
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|
Chronic heart diseasee |
2084 (11.4) |
1324 (14.7) |
< 0.001 |
3408 (12.5) |
|
|
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|
Chronic liver disease |
383 (2.1) |
239 (2.7) |
0.004 |
622 (2.3) |
|
|
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|
Chronic nephropathy |
44 (2.4) |
214 (2.4) |
0.786 |
658 (2.4) |
|
|
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|
Diabetes mellitus |
3713 (20.4) |
2192 (24.4) |
< 0.001 |
5905 (21.7) |
|
|
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|
Hypertension |
9245 (50.7) |
5304 (59.1) |
< 0.001 |
14549 (53.5) |
|
|
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|
Hypercholesterolemia |
6351 (34.9) |
3611 (40.2) |
< 0.001 |
9962 (36.6) |
|
|
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|
Obesity (BMI > 30) |
5089 (27.9) |
3150 (35.1) |
< 0.001 |
8239 (30.3) |
|
|
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|
Smoking status |
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|
|
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|
Non-smoker |
12855 (70.5) |
5826 (64.9) |
< 0.001 |
18681(68.7) |
|
|
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|
Quit |
3479 (19.1) |
2248 (25.0) |
5727(21.1) |
|
|
|
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|
Current |
1889 (10,4) |
907 (10.1) |
2796(10.3) |
|
|
|
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|
Alcoholism |
655 (3.6) |
340 (3.8) |
0.429 |
995 (3.7) |
|
|
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|
Cancer |
1297 (7.1) |
703 (7.8) |
0.035 |
2000 (7.4) |
|
|
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|
Immunosuppressive medication |
772 (4.2) |
425 (4.7) |
0.061 |
1197 (4.4) |
|
|
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|
Immunocompromisef |
1921 (10.5) |
1005 (11.2) |
0.104 |
2926 (10.8) |
|
|
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|
Dementia |
535 (2.9) |
266 (3.0) |
0.905 |
801 (2.9) |
|
|
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|
Nursing-home residence |
265 (1.5) |
110 (1.2) |
0.127 |
375 (1.4) |
|
|
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|
a An amount of 6,179 individuals were classified as non-immunized because they had received the PPV23 more than 60 months before study start. b p values were calculated with chi-square test. c The mean ages of the unvaccinated and vaccinated subjects were 71.5 years (Standard Deviation, SD: 8.9) and 72.0 years (SD: 7.8) respectively. Mean age of overall study subjects was 71.7 years (SD: 8.6). d The mean number of outpatient visits during previous 12 months were 7.1 (SD: 6.7) in unvaccinated and 8.4 (SD: 6.3) in vaccinated subjects. Mean number of visits among the overall study population was 7.5 (SD: 6.6). e It includes congestive heart failure, hypertensive heart disease, cardiomyopathy, valvulopathy, cardiac dilatation or ventricular hypertrophy. f Immunocompromise was a composite variable defined by the presence of any one of the following: cancer (solid organ or haematological neoplasia), chronic severe nephropathy (nephrotic syndrome, renal failure, dialysis or transplantation), anatomical or functional asplenia, immunodeficiency (including AIDS), and long-term corticosteroid therapy (20 mg/day of prednisone) or another immunosuppressive medication. |
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|
Vila-Corcoles et al. BMC Public Health 2012 12:222 doi:10.1186/1471-2458-12-222 |
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