Email updates

Keep up to date with the latest news and content from BMC Public Health and BioMed Central.

Open Access Research article

Fetal and life course origins of serum lipids in mid-adulthood: results from a prospective cohort study

Per E Gustafsson1*, Urban Janlert2, Töres Theorell3, Hugo Westerlund3 and Anne Hammarström1

Author Affiliations

1 Dept of Public Health and Clinical Medicine, Family Medicine, Umeå University, Umeå, Sweden

2 Dept of Public Health and Clinical Medicine, Epidemiology and Global Health, Umeå University, Umeå, Sweden

3 Stress Research Institute, Stockholm University, Stockholm, Sweden

For all author emails, please log on.

BMC Public Health 2010, 10:484  doi:10.1186/1471-2458-10-484

Published: 16 August 2010

Abstract

Background

During the past two decades, the hypothesis of fetal origins of adult disease has received considerable attention. However, critique has also been raised regarding the failure to take the explanatory role of accumulation of other exposures into consideration, despite the wealth of evidence that social circumstances during the life course impact on health in adulthood. The aim of the present prospective cohort study was to examine the contributions of birth weight and life course exposures (cumulative socioeconomic disadvantage and adversity) to dyslipidemia and serum lipids in mid-adulthood.

Methods

A cohort (effective n = 824, 77%) was prospectively examined with respect to self-reported socioeconomic status as well as stressors (e.g., financial strain, low decision latitude, separation, death or illness of a close one, unemployment) at the ages of 16, 21, 30 and 43 years; summarized in cumulative socioeconomic disadvantage and cumulative adversity. Information on birth weight was collected from birth records. Participants were assessed for serum lipids (total cholesterol, low- and high-density lipoprotein cholesterol and triglycerides), apolipoproteins (A1 and B) and height and weight (for the calculation of body mass index, BMI) at age 43. Current health behavior (alcohol consumption, smoking and snuff use) was reported at age 43.

Results

Cumulative life course exposures were related to several outcomes; mainly explained by cumulative socioeconomic disadvantage in the total sample (independently of current health behaviors but attenuated by current BMI) and also by cumulative adversity in women (partly explained by current health behavior but not by BMI). Birth weight was related only to triglycerides in women, independently of life course exposures, health behaviors and BMI. No significant association of either exposure was observed in men.

Conclusions

Social circumstances during the life course seem to be of greater importance than birth weight for dyslipidemia and serum lipid levels in adulthood.