Table 1

Detailed description of each component of the transmission function

Component of transmission function


Ptrans(Ii, Is)

Probability of disease transmission from infected to susceptible individual.


Disease transmission coefficient, chosen to achieve baseline epidemics with specific R0 values.


Age specific susceptibility of infectee or susceptible individual.


Infectiousness of infector as a function of time since infection and symptomatic status.

AVF(Ii, Is)

Antiviral factor which reduces transmission probability when antiviral based interventions are applied to individuals Ii, Is or both.

The following different situations may arise when we model antiviral effectiveness.

AVF(Ii, Is) = 1 - AVEi

if the infected individual is treated with antiviral drugs and no antiviral prophylaxis is applied to the susceptible individual

AVF(Ii, Is) = 1 - AVEs

if antiviral prophylaxis are applied to the susceptible individual and no antiviral treatment is used with the infected individual

AVF(Ii, Is) = (1-AVEi)*(1-AVEs)

if both infected and susceptible individuals are receiving antiviral drugs for treatment and prophylaxis respectively

AVF(Ii, Is) = 1

if neither infector nor susceptible individuals are receiving antiviral drugs

Halder et al. BMC Public Health 2010 10:168   doi:10.1186/1471-2458-10-168

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