Open Access Open Badges Research article

Hepatotoxicity and effectiveness of a Nevirapine-based antiretroviral therapy in HIV-infected patients with or without viral hepatitis B or C infection in Cameroon

Jules B Tchatchueng Mbougua12, Christian Laurent1*, Charles Kouanfack3, Anke Bourgeois14, Laura Ciaffi5, Alexandra Calmy5, Henri Gwet2, Sinata Koulla-Shiro3, Jacques Ducos6, Eitel Mpoudi-Ngolé7, Nicolas Molinari89 and Eric Delaporte14

Author Affiliations

1 Institut de Recherche pour le Développement, University Montpellier 1, UMR 145, Montpellier, France

2 National advanced school of engineering, University Yaoundé 1, Yaoundé, Cameroon

3 Central Hospital, Yaoundé, Cameroon

4 University Hospital, Department of Infectious and Tropical Diseases, Montpellier, France

5 Médecins Sans Frontières, Geneva, Switzerland

6 University Hospital, Laboratory of viral hepatitis, Montpellier, France

7 Military hospital, Yaoundé, Cameroon

8 Department of Biostatistics, University Montpellier 1, Montpellier, France

9 University Hospital, Department of Biostatistics, Nîmes, France

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BMC Public Health 2010, 10:105  doi:10.1186/1471-2458-10-105

Published: 1 March 2010



Coinfection with hepatitis B virus (HBV) or hepatitis C virus (HCV) in HIV-infected patients receiving a commonly used nevirapine-based antiretroviral therapy is a major concern for African clinicians owing to its high prevalence, the infrequent testing and treatment of viral hepatitis, and the impact of liver disease on the tolerability and effectiveness of anti-HIV treatment. We compared the hepatotoxicity and the immunological, virological and clinical effectiveness of a nevirapine-based antiretroviral therapy between patients infected with HIV only and patients coinfected with hepatitis B or C virus in Cameroon.


A retrospective cohort study was conducted among HIV-1-infected patients. Plasma HBV DNA and HCV RNA were tested in positive or indeterminate samples for HBsAg or HCV antibodies, respectively. All patients received nevirapine and lamivudine plus stavudine or zidovudine.


Of 169 HIV-1-infected patients with a median baseline CD4 count of 135 cells/mm3 (interquartile range [IQR] 67-218), 21% were coinfected with HBV or HCV. In coinfected patients, the median viral load was 2.47 × 107 IU/mL for HBV (IQR 3680-1.59 × 108) and 928 000 IU/mL for HCV (IQR 178 400-2.06 × 106). Multivariate analyses showed that the risk of hepatotoxicity was 2-fold higher in coinfected patients (p < 0.01). The response to antiretroviral therapy was however comparable between monoinfected and coinfected patients in terms of CD4 cell count increase (p = 0.8), HIV-1 viral load below 400 copies/mL (p = 0.9), death (p = 0.3) and death or new AIDS-defining event (p = 0.1). Nevirapine was replaced by a protease inhibitor in 4 patients owing to hepatotoxicity.


This study suggests that the nevirapine-based antiretroviral therapy could be used safely as first-line treatment in patients with low CD4 cell count in Africa despite frequent coinfections with HBV or HCV and infrequent testing of these infections. Although testing for HBV and HCV should be systematically performed before initiating antiretroviral therapy, transaminases elevations at baseline or during treatment should be a decisive argument for testing when hepatitis status is unknown.