Table 1

Study Design for Eight Youth HIV Prevention Interventions in Systematic Review

Project Description


Target Population/Age

Experimental Design & Sample Size

Control or Comparison Condition

Duration of Follow-up

HAPS [32]

[HIV/AIDS Prevention Study] KwaZulu/Natal

Reduce sexual and alcohol risk-taking behaviors

Secondary School students, Grade 9; Ages: 14-16 years

Random assignment at school level; 3 intervention, 2 comparison schools

N = 325 I; N = 336 C; pre-post survey

Standard life skills/life orientation curriculum

Follow up survey: 2 months post-intervention

HealthWise [34]


Reduce STI/HIV transmission, drug/alcohol abuse and increase positive use of leisure time

Secondary school students, Grades 8-9

Ages 12-14 in urban township setting;

Pre-and post-intervention surveys; in 3 8th grade cohorts;

4 intervention, 5 control schools randomly assigned;

N = 901 I; N = 1275 C

Standard life skills/life orientation curriculum

5 waves of data collection for each cohort over 1.5 years

Mpondombili Project [33] KwaZulu/Natal

Promote safer sex behaviors, with emphasis on dual protection, sexual risk-reduction, and promotion of positive gender role norms

Secondary School students: Grades 8-10 in rural secondary schools

Baseline and follow up surveys in 2 intervention and 2 comparison schools, not randomized; N = 442 I; N = 541C

Standard life skills/life orientation curriculum; comparison schools received shortened version of curriculum (delayed)

Follow up survey: 5 months post-intervention

Adolescent Livelihoods[35]


Reduce HIV risks and social vulnerabilities, increase access to 'safe spaces' and life skills

Urban township; Out of school youth aged 16-24; in-school youth aged 14-20

Quasi-experimental; group assignment

2 years

SATZ [31,37,51,52]

CapeTown and Northern Province

To develop, implement and evaluate a school-based health education program aimed at promotion of correct, consistent condom use and delay in sexual debut

School students in urban township and rural area; ages 12-14 in grade 8

1 pre- and 2 post-test assessments within quasi-experimental design; 13 intervention and 13 control schools; not randomized. N = 3625

Comparison schools received delayed intervention

1 year

Stepping Stones[11,38]

Eastern Cape

Promote sexual and reproductive health via HIV prevention and reduction in sexual coercion and intimate partner violence

Semi-urban township; older adolescents and young adults aged 18-24; in- and out-of-school youth

Cluster RCT; matched control group; 35 I clusters; 35 C clusters. Sample size: 2770 N = 1140 I; N = 1081C

Single session on HIV, condoms, safe sexual behaviors

2 years post-intervention with 2 assessments, at 12 months and 24 months

Tshwane Peer Education and Support Programme[36]

Tshwane (Pretoria), Gauteng

Promote accurate information about HIV/AIDS, address peer norms, establish psychosocial support

High school students ages 13-20, in semi-rural secondary schools

13 intervention and 4 control schools; not randomized. Pre-post survey of one selected class in each school.

N = 1572 I; N = 596 C

Ongoing Life Orientation or other HIV prevention activities

18 months

IMAGE - Intervention with Microfinance for AIDS and Gender Equity[12,13]

To evaluate effects of combined microfinance and training intervention on HIV risk behavior

Of 3 evaluation cohorts, one cohort of 14-35 year old women

Cluster RCT; 8 pair-matched villages. N = 130(I); N = 132 (C)

Villages randomised to control received standard of care; available sexual health info; no microfinance

2 years

Harrison et al. BMC Public Health 2010 10:102   doi:10.1186/1471-2458-10-102

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