Table 4

Medication at baseline and at 24 months

Pure Mania

Mixed episode


Baseline

n = 504

Treatment of the episode

24 Months

n = 364

Baseline

n = 262

Treatment of the episode

24 Months

n = 164


Antimanic treatment:

Types of therapy (n,%):

None

184 (37%)

0

9 (2%)*

99 (38%)

0

15 (9%)*

Monotherapy

191 (38%)

187 (37%)*

180 (50%)*

99 (38%)

132 (50%)*

79 (48%)*

Combination

129 (26%)

317 (63%)*

175 (48%)*

64 (24%)

130 (50%)*

70 (43%)*

No. of drugs related to the treatment (n,%):

None

184 (37%)

0

9 (2%)*

99 (38%)

0

15 (9%)*

1

191 (38%)

187 (37%)

180 (49%)*

99 (38%)

132 (50%)

79 (48%)*

2

98 (19%)

241 (48%)

145 (40%)*

41 (16%)

103 (39%)

56 (34%)*

3 and +

31 (6%)

76 (15%)

30 (8%)*

23 (9%)

27 (10%)

14 (9%)*

Types of treatment: (n,% Compared to the population)

Lithium

64 (13%)

70 (14%)

57 (16%)*

36 (14%)

40 (15%)

39 (24%)*

Anticonvulsant

161 (32%)

296 (59%)

187 (51%)

79 (30%)

147 (56%)

72 (44%)

Atypical antipsychotics.

75 (15%)

332 (66%)

212 (58%)

36 (14%)

153 (58%)

85 (52%)

Typical antipsychotics

144 (29%)

163 (32%)

77 (21%)

75 (29%)

67 (26%)

34 (21%)


Compliance:

No prescription

131 (26%)

2 (1%)*

60 (23%)

5 (3%)*

Compliance ≈ 100%

253 (50%)

336 (92%)

147 (56%)

138 (84%)

Compliance ≈ 50%

80 (16%)

20 (5%)

45 (17%)

17 (10%)

No compliance

36 (7%)

5 (1%)

8 (3%)

3 (2%)


Course over 24 months:

Maintains (since baseline) (n,% including LTFup):

Monotherapy

.

.

84 (45%)*

27 (21%)*

Combination

101 (32%)

35 (27%)

The same treatment

129 (26%)*

42 (16%)*

Lithium

33 (47%)

17 (43%)

Anticonvulsant

.

.

121 (41%)*

.

.

38 (26%)*

Atypical antipsychotics.

139 (42%)

48 (31%)

Typical neuroleptics

34 (21%)

12 (18%)

No. of changes of treatment: (n,%)

0

.

.

62 (17%)

.

.

33 (20%)

1

59 (16%)

29 (18%)

2

120 (33%)

63 (38%)

3 and +


Concomitant treatments:

Antidepressants

139 (28%)*

75 (15%)*

98 (27%)*

138 (53%)*

129 (49%)*

91 (55%)*

Benzodiazepines

267 (53%)*

291 (58%)*

132 (37%)

177 (68%)*

187 (71%)*

74 (45%)

Anticholinergic drugs

44 (9%)

41 (8%)

21 (6%)

21 (8%)

27 (10%)

10 (6%)

Hypnotics (others)

156 (31%)

199 (39%)

78 (21%)

92 (35%)

97 (37%)

43 (26%)

Types of antidepressant:

Monotherapy(AD) (n, %):

134 (96%)

73 (97%)

93 (95%)

135 (98%)

127 (98%)

87 (96%)

IRSS

104 (78%)

56 (77%)

74 (80%)

96 (71%)

91 (72%)

65 (75%)

Tricyclic

25 (19%)

13 (18%)

17 (18%)

21 (16%)

15 (12%)

16 (18%)

Others

5 (4%)

4 (5%)

2 (2%)

18 (13%)

21 (17%)

6 (7%)

Combination of AD (n,%):

5 (4%)

2 (3%)

5 (5%)

3 (2%)

2 (2%)

4 (4%)


Compliance: the patient nearly always complies with/accepts his/her treatment for bipolar disorders (≈ 100%), half the time (≈ 50%)

* = There is a significant difference between the Pure Mania and mixed episode patient groups, threshold α = 0.05.

Azorin et al. BMC Psychiatry 2009 9:33   doi:10.1186/1471-244X-9-33

Open Data