Table 1

Clones with differential expression patterns across all patient subgroups

Fold Change


Clone

Symbol

NTD (n = 11)

Typical (n = 19)

Atypical (n = 7)

Penalized F-ratio

p-value

Location


1592837

IFITM2*

2.7

1.5

2.1

11.3

0.024

11p15.5

809910

IFITM3*

4.3

1.6

1.8

10.1

0.032

11p15.5

450533

SERPINA3*

4.5

1.2

7.8

8.4

0.056

14q32.1

1455976

IFITM2*

2.3

1.4

2.3

7.0

0.061

11p15.5

166245

GRIN1

-1.6

-1.3

-1.4

4.7

0.004

9q34.3

362926

PRKACB

1.4

1.7

1.5

4.6

0.012

1p36.1

323371

APP

-2.9

-1.8

-1.7

4.2

0.083

21q21.2

841008

GBP1*

2.0

1.7

-1.0

4.1

0.079

1p22.2

221828

KIF1A

-1.3

-1.5

-1.5

4.0

0.005

2q37.3

853906

HLA-A*

1.1

1.5

1.6

3.8

0.045

6p21.3

363007

AGXT2L1

-1.2

-1.3

-2.5

3.7

0.073

4q25

756556

SERPING1

1.3

1.2

1.4

3.6

0.048

11q12-q13.1

214162

MT1H

1.5

1.5

1.1

3.5

0.056

16q13

41447

AGTRL1

1.3

1.2

1.3

3.2

0.025

11q12

45544

TAGLN2

1.3

1.4

1.1

3.1

0.082

1q21-q25

44310

ELL

-1.9

1.3

-3.1

2.9

0.153

19p13.1

487777

RB1

1.1

1.3

1.4

2.8

0.063

13q14.2

245774

C10orf10

1.4

-1.1

2.2

2.8

0.136

10q11.21

173145

CLIPR-59

-2.1

-1.1

-1.2

2.8

0.091

19q13.12

703479

HDHD1A

1.2

1.3

1.3

2.7

0.010

Xp22.32

244147

In multiple UG-clusters

1.3

2.2

1.2

2.7

0.095

839374

EXTL2

-1.6

-1.3

-1.1

2.7

0.032

1p21

1908973

CART

1.1

1.3

1.4

2.6

0.052

5q13.2


Schizophrenic patients were subdivided according to the antipsychotic medication received at death, and pooled brain samples were hybridized onto human cDNA microarrays. Twenty-three clones with large and consistent mRNA differences in all three sub-groups are listed together with their ranking statistic and parametric p-value. Four false positives are expected by chance in the list. Genes with a biological function involved in immune response (*, GO:0006955) were overrepresented in the list (p-value < 0.01). Listed P-values correspond to the parametric test of the average effect (across the subgroups) being different from the control (n = 3).

Saetre et al. BMC Psychiatry 2007 7:46   doi:10.1186/1471-244X-7-46

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