Table 4

Summary of efficacy measures


Baseline, mean (SD)
Endpoint, mean (SD)
p-valuea

Hamilton Rating Scale for Depression total score (n = 511)
23.7 (3.6)
9.9 (7.7)
T = -39.1, df = 510, p < .001
Hamilton Rating Scale for Depression subscales (n = 511)



     Core
9.5 (1.7)
3.4 (3.7)
T = -37.2, df = 510, p < .001
     Maier
12.2 (2.0)
4.5 (4.4)
T = -38.1, df = 510, p < .001
     Anxiety/Somatization
7.6 (1.9)
3.6 (2.7)
T = -30.7, df = 510, p < .001
     Retardation
8.2 (1.5)
3.4 (3.1)
T = -35.3, df = 510, p < .001
     Sleep
3.8 (1.7)
1.7 (1.8)
T = -23.5, df = 510, p < .001
Clinical Global Impression of Severity (n = 512)
4.6 (0.6)
2.3 (1.3)
T = -36.1, df = 511, p < .001
Patient Global Impression of Improvement (n = 511)
N/A
2.6 (1.4)
N/A

LOCF mean change analysis

a p-values are from paired t-test for mean change from baseline to endpoint = 0.

Hudson et al. BMC Psychiatry 2007 7:43   doi:10.1186/1471-244X-7-43