Table 1 |
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|
Psychiatric symptoms and disease activity among adolescent CD patients (n = 7, mean ± SD) |
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|
0 (baseline) |
1–2 months |
p-value1) |
3 months |
p-value1) |
6 months |
p-value2) |
|
|
|
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|
CGAS 3) |
74.4 (± 16.5)4) |
86.9 (± 5.6) |
0.043 |
88.3 (± 9.2) |
0.006 |
||
|
HAM-D5) |
5.7 (± 7.3) |
0.3 (± 0.8) |
0.043 |
1.0 (± 1.3) |
0.009 |
||
|
HAM-A6) |
6.9 (± 6.9) |
0.1 (± 0.4) |
0.043 |
0.7 (± 1.3) |
0.010 |
||
|
BDI7) |
3.4 (± 6.5) |
0.0 (± 0.0) 8) |
n.s.9) |
0.1 (± 0.4) |
0.041 |
0.6 (± 1.1) |
0.014 |
|
BAI10) |
3.0 (± 2.9) |
1.3 (± 1.5) 8) |
n.s. |
0.7 (± 1.1) |
0.042 |
1.4 (± 2.2) |
n.s. |
|
CBCL11) Total problems |
28.3 (± 12.8) |
18.4 (± 6.9) |
0.028 |
14.0 (± 9.5) |
0.028 |
18.4 (± 16.2) |
0.007 |
|
Anxious/depressed |
3.9 (± 3.1) |
1.4 (± 1.7) |
0.046 |
1.3 (± 1.5) |
0.026 |
1.3 (± 1.1) |
0.033 |
|
Aggressive behaviour |
7.3 (± 4.2) |
5.6 (± 2.2) |
n.s. |
3.6 (± 3.1) |
0.039 |
6.0 (± 6.4) |
0.047 |
|
YSR12) Total problems |
24.4 (± 13.8) |
17.0 (± 12.5) |
n.s. |
8.0 (± 7.8) |
0.018 |
9.4 (± 7.4) |
0.001 |
|
Anxious/depressed |
2.7 (± 3.4) |
1.6 (± 2.2) |
n.s. |
0.3 (± 0.5) |
0.026 |
0.6 (± 1.0) |
0.002 |
|
Aggressive behaviour |
5.1 (± 2.7) |
4.1 (± 2.7) |
n.s. |
2.0 (± 2.2) |
0.044 |
2.4 (± 1.4) |
0.021 |
|
Somatic complains |
4.9 (± 2.4) |
3.1 (± 2.3) |
0.038 |
2.1 (± 1.2) |
0.026 |
2.3 (± 2.1) |
0.003 |
|
S-EndoAbA8) |
800(200–1600) |
200 (5–400) |
0.018 |
5 (5–1600) |
0.027 |
5 (5–100) |
0.001 |
|
S-tTGAbA |
139 (± 158) |
30 (± 35) |
0.018 |
19 (± 26) |
0.018 |
7 (± 8) |
< 0.001 |
|
Prolactin (mU/l)13) |
1569 (± 767) |
218 (± 60) |
0.028 |
284 (± 170) |
0.018 |
205 (± 92)14) |
0.019 |
|
S-T4/TSH (nmol/l:mU/l) |
34 (± 6) |
64 (± 38)14) |
0.043 |
84 (± 53) |
0.043 |
74 (± 32)15) |
0.039 |
|
|
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|
1) non-parametric Wilcoxon signed-ranks test; compared with baseline; 2) repeated measures non-parametric Friedman test; 3) Children's Global Assessment; 4) mean ± SD; 5) Hamilton Depression Rating Scale; 6) Hamilton Anxiety Rating Scale ; 7) Beck Depression Inventory; 8) median (min-max); 9) non significant; 10) Beck Anxiety Inventory; 11) Child Behavior Checklist; 12) Youth Self Report; 13) normal: females 50–300, males 50–500; 14) n = 6 ; 15) n = 4 |
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|
Pynnönen et al. BMC Psychiatry 2005 5:14 doi:10.1186/1471-244X-5-14 |
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