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Open Access Research article

Social insecurity in relation to orbitofrontal activity in patients with eating disorders: a near-infrared spectroscopy study

Hiroto Katayama1, Kunihiro Kohmura1, Satoshi Tanaka2*, Miho Imaeda1, Naoko Kawano1, Yukihiro Noda34, Kazuo Nishioka1, Masahiko Ando5, Branko Aleksic1, Tetsuya Iidaka1 and Norio Ozaki1

Author Affiliations

1 Department of Psychiatry, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi-ken 466-8550, Japan

2 Department of Psychiatry, Nagoya University Hospital, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi-ken 466-8550, Japan

3 Division of Clinical Science and Neuropsychopharmacology, Graduate School of Pharmacy, Meijo University, 150 Yagotoyama, Tenpaku-ku, Nagoya, Aichi-ken 468-8503, Japan

4 The Academic Frontier Project for Private Universities, Comparative Cognitive Science Institutes, Meijo University, 1-501 Shiogamaguchi, Tenpaku-ku, Nagoya, Aichi-ken 468-8502, Japan

5 Center for Advanced Medicine and Clinical Research, Nagoya University Hospital, Nagoya, Aichi-ken 466-8550, Japan

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BMC Psychiatry 2014, 14:173  doi:10.1186/1471-244X-14-173

Published: 12 June 2014

Abstract

Background

Functional neuroimaging techniques are widely used to elucidate changes in brain activity, and various questionnaires are used to investigate psychopathological features in patients with eating disorders (ED). It is well known that social skills and interpersonal difficulties are strongly associated with the psychopathology of patients with ED. However, few studies have examined the association between brain activity and social relationships in patients with ED, particularly in patients with extremely low body weight.

Methods

In this study, 22-channel near-infrared spectroscopy was used to quantify regional hemodynamic changes during a letter fluency task (LFT) in 20 female patients with ED with a mean body mass index of 14.0 kg/m2and 31 female controls (CTLs). Symptoms were assessed using the Eating Disorder Inventory-2 and Beck Depression Inventory. We hypothesized that frontal activity in patients with ED would be lower than in CTLs and would show different correlations with psychopathological features compared with CTLs.

Results

The LFT performance and score on the social insecurity subscale of the Eating Disorder Inventory-2 were significantly higher in the ED group than in the CTL group. The mean change in oxygenated hemoglobin (oxy-Hb) in bilateral frontal regions during the LFT was significantly smaller in the ED group than in the CTL group. Social insecurity score was positively correlated with the concentration of oxy-Hb in the bilateral orbitofrontal cortex in the ED group but not in the CTL group.

Conclusions

These results suggest that activity of the orbitofrontal cortex is associated with social insecurity and disturbed in patients with ED. Therefore, disturbed orbitofrontal cortex activity may underlie the lack of insight and social isolation that is characteristic of patients with ED.

Keywords:
Anorexia nervosa; Extremely low body weight; Near-infrared spectroscopy; Social isolation