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Open Access Research article

Association of the 5HTR2A gene with suicidal behavior: CASE-control study and updated meta-analysis

Thelma Beatriz González-Castro1, Carlos Tovilla-Zárate27*, Isela Juárez-Rojop1, Sherezada Pool García3, Martha Patricia Velázquez-Sánchez3, Alma Genis4, Humberto Nicolini4 and Lilia López Narváez56

Author Affiliations

1 División Académica de Ciencias de la Salud, Universidad Juárez Autónoma de Tabasco, Villahermosa, Tabasco, México

2 División Multidisciplinaria de Comalcalco, Universidad Juárez Autónoma de Tabasco, Comalcalco, Tabasco, México

3 Hospital General de Comalcalco, Tabasco, Secretaría de Salud, Comalcalco, Tabasco, México

4 Grupo de Estudios Médicos y Familiares Carracci, México, DF, México

5 CIGEN, Centro de Investigación Genómica, Comalcalco, Tabasco, México

6 Hospital General de Yajalón, Yajalón, Chiapas, México

7 División Académica Multidisciplinaria de Comalcalco, Ranchería Sur, Cuarta Sección, C.P. 86650, Comalcalco, Tabasco, México

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BMC Psychiatry 2013, 13:25  doi:10.1186/1471-244X-13-25

Published: 12 January 2013

Abstract

Background

The polymorphism rs6313 (T102C) has been associated with suicidal behavior in case–control and meta-analysis studies, but results and conclusions remain controversial. The aim of the present study was to examine the association between T102C with suicidal behavior in a case–control study and, to assess the combined evidence – this case–control study and available data from other related studies – we carried out a meta-analysis.

Methods

We conducted a case–control study that included 161 patients with suicide attempts and 244 controls; we then performed a meta-analysis. The following models were evaluated in the meta-analysis: A) C allele vs T allele; B) T allele vs C allele; C) Caucasian population, D) Asian population, and E) suicide attempters with schizophrenia.

Results

We found an association between attempted suicide and control participants for genotype (χ2=6.28, p=0.04, df=2) and allele (χ2=6.17, p=0.01, df=1, OR 1.48 95% IC: 1.08-2.03) frequencies in the case–control study. The meta-analysis, comprising 23 association studies (including the present one), showed that the rs6313 polymorphism is not associated with suicidal behavior for the following comparisons:T allele vs C allele (OR: 1.03; 95% CI 0.93-1.13; p(Z)=0.44); C allele vs T allele: (OR:0.99; 95% CI: 0.90-1.08; p(Z)=0.22); Caucasians (OR:1.09; 95% CI: 0.96-1.23), and Asians (OR:0.96; 95% CI: 0.84-1.09).

Conclusion

Our results showed association between the rs6313 (T102C) polymorphism and suicidal behavior in the case–control study. However, the meta-analysis showed no evidence of association. Therefore, more studies are necessary to determine conclusively an association between T102C and suicidal behavior.