Table 2

Primary and secondary analyses, change from baseline to 2-hour timepoint (LOCF)
IM Olz, 10 mg (N=45) IM Placebo (N=44) p valueb
Mean (points) SD 95%CI Mean (points) SD 95%CI
Baseline
 PANSS-EC total 23.5 6.1 21.7, 25.4 23.3 4.9 21.8, 24.8 .638
  Poor impulse control 4.8 1.2 4.5, 5.2 4.7 1.2 4.3, 5.0 .336
  Tension 4.7 1.6 4.2, 5.2 4.7 1.1 4.3, 5.0 .722
  Hostility 4.6 1.6 4.1, 5.1 4.6 1.3 4.2, 5.0 .912
  Uncooperativeness 4.7 1.3 4.3, 5.1 4.8 1.2 4.4, 5.1 .791
  Excitement 4.7 1.2 4.4, 5.1 4.6 1.0 4.3, 4.9 .385
 ACESa 1.6 0.5 1.5, 1.7 1.6 0.5 1.5,1.8 .741
2 hours
 PANSS-EC total 14.3 6.0 12.5, 16.1 20.5 7.5 18.3, 22.8
  Poor impulse control 3.0 1.3 2.6, 3.4 4.1 1.5 3.7, 4.6
  Tension 2.9 1.2 2.5, 3.2 4.1 1.7 3.6, 4.6
  Hostility 2.8 1.3 2.4, 3.1 4.0 1.7 3.5, 4.5
  Uncooperativeness 2.9 1.4 2.5, 3.3 4.3 1.6 3.8, 4.8
  Excitement 2.8 1.2 2.4, 3.2 4.0 1.5 3.5, 4.4
 ACES 3.5 1.7 2.9, 4.0 2.2 1.3 1.8, 2.6
Change, baseline-2 hours
 PANSS-EC Total −9.2 4.5 −10.6, -7.9 −2.8 5.6 −4.5, -1.1 <.001
  Poor impulse control −1.9 1.0 −2.2, -1.6 −0.6 1.2 −0.9, -0.2 <.001
  Tension −1.8 1.1 −2.2, -1.5 −0.6 1.1 −0.9, -0.2 <.001
  Hostility −1.8 1.2 −2.2, -1.5 −0.6 1.5 −1.0, -0.1 <.001
  Uncooperativeness −1.7 0.9 −2.0, -1.5 −0.5 1.2 −0.8, -0.1 <.001
  Excitement −1.9 1.1 −2.3, -1.6 −0.6 1.4 −1.0, -0.2 <.001
 ACES 1.9 1.5 1.4, 2.3 0.6 1.1 0.2, 0.9 <.001

Abbreviations: ACES=Agitation-Calmness Evaluation Scale; CI=confidence interval; IM Olz=intramuscular olanzapine; LOCF=last observation carried forward [analysis]; N=number of patients with a baseline and a value at the time (LOCF); PANSS-EC=Positive and Negative Syndrome Scale-Excited Component.

aAt baseline placebo n=45.

bp value: ANOVA model which includes Treatment and Site as factors.

Katagiri et al.

Katagiri et al. BMC Psychiatry 2013 13:20   doi:10.1186/1471-244X-13-20

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