Table 2

Test performance (T-scores) for the total sample, BD I and BD II subsamples in inpatients with therapy-resistant BD depression on nine cognitive tasks from the MCCB, six domain scores and mean composite score, and IQ, and change in IQ from the estimated premorbid level
Neurocognitive domain Total sample BD I BD II ANOVA
  Test n= 51 n= 19 n= 32 F p η2
Mean (SD) Mean (SD) Mean (SD)
Speed of processing 36.5 (12.3) 32.3 (14.6) 39.0 (10.2) 3.69 0.061) 0.07
  BACS–Symbol Coding 37.0 (11.7) 35.0 (13.6) 38.2 (10.5) 0.672)
  Fluency 44.7 (9.5) 40.7 (10.5) 47.1 (8.1) 5.91 0.021) 0.11
  TMT-A 37.7 (13.1) 33.7 (13.5) 40.0 (12.6) 2.77 0.101) 0.05
Attention/Vigilance 40.7 (11.4)a 38.5 (11.8)b 41.8 (11.3)c 0.78 0.381) 0.02
  CPT
Working memory 43.5 (11.2) 41.2 (11.1) 45.0 (11.3) 1.37 0.251) 0.03
  Spatial Span 45.9 (10.6)d 44.2 (10.8) 47.0 (10.5)e 0.80 0.381) 0.02
  Letter-Number Span 43.5 (10.7) 41.2 (10.7) 44.9 (10.7) 1.45 0.241) 0.03
Verbal learning 38.4 (8.1) 36.5 (7.6) 39.5 (8.2) 1.73 0.191) 0.03
  HVLT-R
Visual learning 43.0 (11.7)f 40.7 (13.7)g 44.3 (10.4)h 1.04 0.311) 0.02
  BVMT-R
Reasoning 42.3 (9.3)d 41.9 (7.8)g 42.4 (10.1) 0.812)
  Mazes
Mean composite score 40.6 (8.4) 38.4 (9.3) 41.9 (7.7) 2.19 0.141) 0.04
IQ 102.3 (13.6) 93.9 (15.2) 107.2 (10.2) 14.05 <0.011) 0.22
  WASI
IQ difference 10.8 (13.0)i 18.0 (13.7)g 6.1 (10.3)j 11.29 <0.011) 0.20
  NART-WASI

Note: Scores on the MCCB measures have a mean of T = 50 and an SD of T = 10. IQ scores have a mean of 100 and an SD of 15. p values for statistical comparisons between BD subtypes: 1)ANOVA; 2)Mann-Whitney Test. Data presented in bold, p < 0.05.

MCCB, Measurement and treatment research to improve cognition in schizophrenia (MATRICS) consensus cognitive battery; ANOVA, Analysis of variance; BACS, Brief assessment of cognition in schizophrenia; TMT-A, Trail-making test, part A; CPT, Continuous performance test; HVLT-R, Hopkins verbal learning test–revised; BVMT-R, Brief visuospatial memory test–revised; WASI, Wechsler abbreviated scale of intelligence; NART, National adult reading test.

an = 44, bn = 14, cn = 30, dn = 50, en = 31, fn = 49, gn = 18, hn = 31, in = 46, jn = 28 due to missing data.

Kessler et al.

Kessler et al. BMC Psychiatry 2013 13:105   doi:10.1186/1471-244X-13-105

Open Data