Risk factors for suicide behaviors in the observational schizophrenia outpatient health outcomes (SOHO) study
1 Italian Foundation for the study of Schizophrenia, Rome, Italy
2 Eli Lilly and Company, Windlesham, Surrey, UK
3 Parc Sanitari Sant Joan de Déu, CIBERSAM, Sant Boi de Llobregat, Barcelona, Spain
4 Medical Department, Eli Lilly, Florence, Italy
5 Psychiatric Dept. “Villa S. Chiara” Nursing home, Verona, Italy
6 Affective Disorders Unit, Lime Tree Park Nursing Home, Villa di Teolo (Padova), Italy
7 Affective Disorders Unit, Casa Di Cura Parco dei Tigli, via Monticello 1, Villa di Teolo, 35037, Padova, Italy
BMC Psychiatry 2012, 12:83 doi:10.1186/1471-244X-12-83Published: 19 July 2012
To identify risk factors for suicide using data from a large, 3-year, multinational follow-up study of schizophrenia (SOHO study).
Baseline characteristics of 8,871 adult patients with schizophrenia were included in a logistic regression post-hoc analysis comparing patients who attempted and/or committed suicide during the study with those who did not.
384 (4.3%) patients attempted or committed suicide. Completed suicides were 27 (0.3%). The significant risk factors for suicide behaviors were previous suicidality, depressive symptoms, prolactin-related adverse events, male gender and history of hospitalization for schizophrenia.
In view of the observational design of the study and the post-hoc nature of the analysis, the identified risk factors should be confirmed by ad-hoc specifically designed studies.