Open Access Research article

Risk factors for suicide behaviors in the observational schizophrenia outpatient health outcomes (SOHO) study

Roberto Brugnoli1, Diego Novick2, Josep Maria Haro3, Andrea Rossi4, Marco Bortolomasi5, Sonia Frediani4 and Giuseppe Borgherini67*

Author Affiliations

1 Italian Foundation for the study of Schizophrenia, Rome, Italy

2 Eli Lilly and Company, Windlesham, Surrey, UK

3 Parc Sanitari Sant Joan de Déu, CIBERSAM, Sant Boi de Llobregat, Barcelona, Spain

4 Medical Department, Eli Lilly, Florence, Italy

5 Psychiatric Dept. “Villa S. Chiara” Nursing home, Verona, Italy

6 Affective Disorders Unit, Lime Tree Park Nursing Home, Villa di Teolo (Padova), Italy

7 Affective Disorders Unit, Casa Di Cura Parco dei Tigli, via Monticello 1, Villa di Teolo, 35037, Padova, Italy

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BMC Psychiatry 2012, 12:83  doi:10.1186/1471-244X-12-83

Published: 19 July 2012



To identify risk factors for suicide using data from a large, 3-year, multinational follow-up study of schizophrenia (SOHO study).


Baseline characteristics of 8,871 adult patients with schizophrenia were included in a logistic regression post-hoc analysis comparing patients who attempted and/or committed suicide during the study with those who did not.


384 (4.3%) patients attempted or committed suicide. Completed suicides were 27 (0.3%). The significant risk factors for suicide behaviors were previous suicidality, depressive symptoms, prolactin-related adverse events, male gender and history of hospitalization for schizophrenia.


In view of the observational design of the study and the post-hoc nature of the analysis, the identified risk factors should be confirmed by ad-hoc specifically designed studies.

Suicide; Schizophrenia; Observational study