Table 4

Quadratic correlations of demographics and clinical variables to patient anterior insula GMV
Demographic/clinical variable Left anterior insula Right anterior insula
Predicted IQ r(117) = .03 r(117) = .04
Age of onset of illness r(124) = .07 r(124) = .09
Years of Education r(125) = .16 r(125) = .13
Antidepressant dose (mg/day) r(64) = .13 r(64) = .06
Antipsychotic dose (mg/day) r(60) = .20 r(60) = .26
Mood stabiliser dose (mg/day) r(25) = .25 r(25) = .17
Social and occupational functioning (SOFAS) r(119) = .12 r(119) = .13
Psychological distress (K-10) r(125) = .12 r(125) = .10
Depression (HDRS) r(121) = .17 r(121) = .19
Depression (DASS Depression subscore) r(116) = .13 r(116) = .02
Anxiety (DASS Anxiety subscore) r(116) = .14 r(116) = .13
Stress (DASS Stress subscore) r(116) = .19 r(116) = .09
Social interaction anxiety (SIAS) r(122) = .20 r(122) = .28**
Symptom severity (BPRS Total) r(117) = .17 r(117) = .29**
Positive symptoms (BPRS Positive Symptoms subscore) r(117) = .17 r(117) = .32**
Negative symptoms (BPRS Negative Symptoms subscore) r(117) = .10 r(117) = .06
Depression (BPRS Depression subscore) r(117) = .07 r(117) = .10
Mania (BPRS Mania subscore) r(116) = .16 r(116) = .22

Curve estimation regression explored the quadratic correlations between the left or right anterior insula GMV (corrected for ICV) with patient demographic and clinical variables (n = 133). **p < .01 (2-tailed).

Hatton et al.

Hatton et al. BMC Psychiatry 2012 12:45   doi:10.1186/1471-244X-12-45

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