Open Access Research article

Abnormalities in gamma-band responses to language stimuli in first-degree relatives of children with autism spectrum disorder: an MEG study

Kristina L McFadden1, Susan Hepburn12, Erin Winterrowd3, Gwenda L Schmidt4 and Donald C Rojas1*

Author Affiliations

1 Department of Psychiatry at the University of Colorado Denver Anschutz Medical Campus, 13001 E. 17th Place, Aurora, CO, 80045, USA

2 JFK Partners at the University of Colorado Denver Anschutz Medical Campus, 13121 E. 17th Ave, Aurora, CO, 80045, USA

3 Department of Psychology, University of Wisconsin Oshkosh, 800 Algoma Blvd, Oshkosh, WI, 54901, USA

4 Department of Psychology, Hope College, 35 E 12th St, Holland, MI, 49423, USA

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BMC Psychiatry 2012, 12:213  doi:10.1186/1471-244X-12-213

Published: 29 November 2012

Additional files

Additional file 1:

Figure S1. Statistical results of an independent-samples t-test comparison between sensor-level neural activity in parents of a child with an autism spectrum disorder (pASD) and healthy adult control participants. Time and frequency windows of interested are represented as follows: A) early (30-150 ms) evoked gamma-band activity (30-50 Hz), B) late (200-800 ms) evoked gamma-band activity, C) early evoked beta-band activity (13-30 Hz), and D) late evoked beta-band activity. Sensors demonstrating a statistically significant group difference (uncorrected p < .01) are indicated with an asterisk overlayed on the sensor. Statistical values above 0 indicate areas in which pASD showed greater evoked activity compared to controls; those below 0 indicate areas in which pASD showed less activity than controls (pASD > HC shown in warmer colors; HC > pASD shown in cooler colors).

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