Table 4

Effects of the exclusion criteria on treatment outcome in ROM patients suffering from MDD
Definition of outcome Influence on outcome in all patients Influence on outcome in all patients adjusted1 Influence on outcome in psychotherapy patients Influence on outcome in psychotherapy patients adjusted1
Current or past abuse or dependence on alcohol
ΔMADRS B = 2.77 B=2.09 - -
95% CI −0.85-6.39 95% CI: -1.50 -5.68
p=0.13 p=0.25
Proportion of responders OR = 2.12 OR 2.36 - -
95% CI 0.80-5.63 95% CI 0.80-7.03
p=0.13 p=0.13
Proportion of remitters OR = 1.95 OR 2.10 - -
95% CI 0.67-5.68 95% CI 0.61-7.27
p=0.22 p=0.24
Current or past abuse or dependence on drugs
ΔMADRS B = − 0.17 B= −1.12 B=3.37 B=3.50
95% CI −5.35-5.02 95% CI: -6.04 -3.79 95% CI −1.04 – 7.78 95%CI −8.51-7.85
p=0.95 p=0.65 p=0.13 p=0.11
Proportion of responders OR = 0.73 OR 0.70 OR 1.72 OR 1.52
95% CI 0.24-2.22 95% CI 0.22-2.15 95% CI 0.17-17.40 95% CI 0.13-17.78
p=0.58 p=0.53 p=0.65 p=0.74
Proportion of remitters OR = 0.72 OR 0.77 OR 1.19 OR 0.88
95%CI 0.22-2.34 95% CI 0.23-2.54 95%CI 0.12-12.08 95% CI 0.07-10.39
p=0.59 p=0.66 p=0.88 p=0.92
Not meeting a minimum baseline severity threshold
ΔMADRS B = 6.39* B=7.23* B=3.37 B=3.50
95%CI 4.56-8.21 p<0.001 95%CI 5.31-9.14 p<0.001 95% CI −1.04–7.78 95% CI −8.51-7.85
p=0.13 p=0.11
Proportion of responders OR = 1.28 OR 1.53 OR 0.90 OR 0.87
95% CI 0.83-2.00 95% CI 0.94-2.47 95% CI 0.33-2.45 95% CI 0.31-2.50
p=0.27 p=0.09 p=0.84 p=0.80
Proportion of remitters OR = 0.46* OR 0.53* OR 0.53 OR 0.49
95%CI 0.30-0.70 95% CI 0.33-0.84 95% CI 0.19-1.49 95% CI 0.17-1.45,
p<0.001 p=0.01 p=0.23 p=0.20
Previous use of medication or ECT
ΔMADRS B = 1.26 B=1.19 B=7.62* B=5.49
95%CI −0.42-2.95 95%CI −0.45 – 2.83 p=0.15 95%CI 1.94-13.30 95% CI −0.67-11.65
p=0.14 p<0.01 p=0.08
Proportion of responders OR = 1.47 OR 1.39 OR 6.75 OR 5.46
95% CI 1.0-2.17 95% CI 0.93-2.08 95% CI 0.82-55.83 95% CI 0.61-48.68
p=0.05 p=0.11 p=0.08 p=0.13
Proportion of remitters OR = 1.53 OR 1.37 OR 4.57 OR 4.04
95% CI 1.00-2.34 95% CI 0.88-2.13 95% CI 0.55-38.01 95% CI 0.44-37.26
p=0.05 p=0.16 p=0.16 p=0.22

Caption:

* = exclusion of patients who meet this criterion contributes significantly to treatment outcome.

1 Adjusted= adjusted for age, gender and treatment modality (only in all MDD patients) and for all other exclusion criteria in the model.

B= regression coefficient: amount of additional improvement on the MADRS when patients who meet this exclusion criterion are excluded.

OR= odds ratio, the chance of response or remission when patients who meet this exclusion criterion are excluded in relation to the chance of response or remission when these patients are not excluded.

95% CI= 95% confidence interval.

van der Lem et al.

van der Lem et al. BMC Psychiatry 2012 12:192   doi:10.1186/1471-244X-12-192

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