Open Access Research article

Reduced antioxidant defense in early onset first-episode psychosis: a case-control study

Juan Antonio Micó1, Maria Olga Rojas-Corrales1, Juan Gibert-Rahola1, Mara Parellada2, Dolores Moreno2, David Fraguas3, Montserrat Graell4, Javier Gil5, Jon Irazusta5, Josefina Castro-Fornieles6, Cesar Soutullo7, Celso Arango2, Soraya Otero8, Ana Navarro9, Inmaculada Baeza6, Mónica Martínez-Cengotitabengoa9 and Ana González-Pinto10*

Author Affiliations

1 Department of Neuroscience, Pharmacology and Psychiatry, School of Medicine, CIBERSAM, Centro de Investigación Biomédica en Red de Salud Mental. University of Cádiz, Spain

2 Adolescent Unit, Department of Psychiatry, Hospital General Universitario Gregorio Marañón, CIBERSAM, Centro de Investigación Biomédica en Red de Salud Mental Madrid, Spain

3 Mental Health Service. University Hospital, Albacete. Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Spain

4 Section of Child and Adolescent Psychiatry and Psychology, Hospital Infantil Universitario Niño Jesús, Madrid, Spain

5 Department of Physiology, Faculty of Medicine and Dentistry, University of the Basque Country, Bilbao, Bizkaia, Spain

6 Department of Child and Adolescent Psychiatry and Psychology, Institut Clinic of Neurosciences, IDIBAPS, (Institut d'Investigacions Biomèdiques August Pi Sunyer), Hospital Clínic Universitari of Barcelona, CIBERSAM, Centro de Investigación Biomédica en Red de Salud Mental, Spain

7 Child & Adolescent Psychiatry Unit, Department of Psychiatry & Medical Psychology, University of Navarra, Pamplona, Spain

8 Child And Adolescent Psychiatry Unit, Department of Psychiatry, Valdecilla Universiy Hospital, Santander, Cantabria, Spain

9 Department of Biochemistry and Molecular Biology, School of Medicine, University of Cádiz, CIBERSAM, Centro de Investigación Biomédica en Red de Salud Mental, Spain

10 Hospital Santiago, Department of Psychiatry, CIBERSAM, Centro de Investigación Biomédica en Red de Salud Mental, University of the Basque Country, Olaguibel 29, Vitoria, Spain

For all author emails, please log on.

BMC Psychiatry 2011, 11:26  doi:10.1186/1471-244X-11-26

Published: 14 February 2011

Abstract

Background

Our objective is to determine the activity of the antioxidant defense system at admission in patients with early onset first psychotic episodes compared with a control group.

Methods

Total antioxidant status (TAS) and lipid peroxidation (LOOH) were determined in plasma. Enzyme activities and total glutathione levels were determined in erythrocytes in 102 children and adolescents with a first psychotic episode and 98 healthy controls.

Results

A decrease in antioxidant defense was found in patients, measured as decreased TAS and glutathione levels. Lipid damage (LOOH) and glutathione peroxidase activity was higher in patients than controls. Our study shows a decrease in the antioxidant defense system in early onset first episode psychotic patients.

Conclusions

Glutathione deficit seems to be implicated in psychosis, and may be an important indirect biomarker of oxidative stress in early-onset schizophrenia. Oxidative damage is present in these patients, and may contribute to its pathophysiology.