Table 2

Study characteristics

Study

Number of participants

Blinding

Design

Follow-up

Baseline severity ADHD-RS total score

Mean daily dose-atomoxetine and frequency

Mean daily dose-methylphenidate and frequency


Yildiz

2010

n = 25

Open label

Parallel group

12 weeks

Parents T-DSM-IV inattention scores

atomoxetine = 16.72

MPH = 17.72

1.28 mg/kg/day

Once a day

OROS-MPH = 1.07 mg/kg

(IR = equivalent 0.89 mg/kg)

Once a day

Newcorn 2008

n = 442

Double blind

Parallel group

6 weeks

Atomoxetine = 40.9(SD 8.8)

MPH = 40.0

(SD 8.8)

1.45 mg/kg

Twice a day

OROS-MPH =

1.16 mg/kg

(IR equivalent = 0.966 mg/kg

Once a day

Prasad 2007

n = 180

Open label

Parallel group

10 weeks

Atomoxetine = 45.5(SD 8.7)

MPH not stated

1.5 mg/kg

Once a daily

8 pts got twice daily

IR MPH = 0.8 mg/kg

OROS-MPH = 1.03 mg/kg

(IR equivalent = 0.858 mg/kg)

Wang

2007

n = 330

Double blind

Parallel group

8 weeks

Atomoxetine = 38.6 (SD 7.6)

MPH = 37.4

(SD 7.6)

Final range

0.8 mg/kg-1.8 mg/kg

Once a day

IR MPH = 17.8/mg/day

Twice a day

Kemner 2005

n = 1323

Open label

Parallel group

3 weeks

Atomoxetine = 38.6 (SD8.1)

MPH = 39.

1.08 mg/kg/Once a day

OROS-MPH 1.01 mg/kg/day

(IR equivalent 0.841 mg/kg) Once a day

Sangal 2005

n = 85

Double blind

Cross over

7 weeks

Atomoxetine = 39.6

MPH not stated

1.56 mg/kg/day

Twice a day

IR MPH = 1.12 mg/kg

Three times a day

Kratochvil 2002

n = 228

Open label

Parallel group

10 weeks

Atomoxetine = 39.4

MPH = 37.6

0.48 mg/kg*

or

1.4 mg/kg/kg**

Twice daily

Final mean dose 0.85 mg/kg

Three times a day

Spencer 2002 HFBD

n = 84

Double blind

Parallel group

9 weeks

Atomoxetine = 39.5

1.56 mg/kg

Twice a day

IR MPH = 1.12 mg/kg

Twice a day

Spencer 2002 HFBK

n = 79

Double blind

Parallel group

9 weeks

Atomoxetine = 39.5

1.56 mg/kg

Twice a day

IR MPH = 1.12 mg/kg

Twice a day


*atomoxetine slow metabolisers **atomoxetine rapid metabolisers

18 mg OROS MPH = 15 mg IR MPH

Hanwella et al. BMC Psychiatry 2011 11:176   doi:10.1186/1471-244X-11-176

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