|
Birth year adjusted analyses of the association between infant characteristics and childhood leukemia. |
|||||||
| Sub-cohort |
ALL |
AML |
|||||
|
|
|||||||
| No. (%) |
No. (%) |
HR |
95% CI |
No. (%) |
HR |
95% CI |
|
|
|
|||||||
| Child gender |
|||||||
| female |
4242 (49) |
227 (41) |
ref. |
43 (49) |
ref. |
||
| male |
4501 (51) |
332 (59) |
1.38 |
1.16–1.64 |
44 (51) |
0.97 |
0.64–1.49 |
| missing |
7 (0) |
1 (0) |
0 (0) |
||||
| Birth weight |
|||||||
| Per 1 sd increase (per 581 grams) |
8710 |
555 |
1.12 |
1.03–1.23 |
87 |
1.33 |
1.06–1.66 |
| Birth weight category |
|||||||
| < 2496 g |
406 (5) |
29 (5) |
1.49 |
0.96–2.30 |
2 (2) |
0.86 |
0.19–3.94 |
| 2496–3117 g |
1746 (20) |
83 (15) |
ref. |
10 (11) |
ref. |
||
| 3118–3458 g |
2192 (25) |
117 (21) |
1.13 |
0.84–1.51 |
23 (26) |
1.85 |
0.88–3.91 |
| 3459–3798 g |
2142 (25) |
152 (27) |
1.48 |
1.12–1.95 |
20 (23) |
1.65 |
0.77–3.54 |
| 3799–4309 g |
1796 (21) |
137 (25) |
1.59 |
1.20–2.11 |
27 (31) |
2.65 |
1.27–5.49 |
| ≥ 4309 g |
428 (5) |
37 (7) |
1.82 |
1.22–2.73 |
5 (6) |
1.96 |
0.66–5.78 |
| missing |
40 (0) |
5 (1) |
0 (0) |
||||
| Size for gestational age* |
|||||||
| small |
271 (3) |
20 (4) |
1.23 |
0.77–1.97 |
2 (2) |
0.78 |
0.19–3.22 |
| average |
5708 (72) |
343 (67) |
ref. |
54 (65) |
ref. |
||
| large |
1905 (24) |
151 (29) |
1.30 |
1.07–1.59 |
27 (33) |
1.51 |
0.95–2.40 |
| missing |
314 (4) |
27 (5) |
1 (1) |
||||
| Gestational age category* |
|||||||
| <37 weeks |
657 (8) |
43 (8) |
1.00 |
0.72–1.38 |
4 (5) |
0.56 |
0.20–1.53 |
| 37–42 weeks |
6938 (88) |
446 (86) |
ref. |
1 (1) |
ref. |
||
| >42 weeks |
311 (4) |
28 (5) |
1.47 |
0.98–2.19 |
2 (2) |
0.59 |
0.14–2.43 |
| missing |
292 (4) |
24 (4) |
1 (1) |
||||
| One minute Apgar score+ |
|||||||
| 0–7 |
1798 (23) |
144 (29) |
1.32 |
1.08–1.61 |
26 (33) |
1.62 |
1.01–2.60 |
| >7 |
5884 (77) |
359 (71) |
ref. |
53 (67) |
ref. |
||
| missing |
336 (4) |
34 (6) |
4 (5) |
||||
| Five minute Apgar score+ |
|||||||
| 0–7 |
275 (4) |
14 (3) |
0.77 |
0.44–1.33 |
4 (5) |
1.47 |
0.53–4.08 |
| >7 |
7394 (96) |
488 (97) |
ref. |
75 (95) |
ref. |
||
| missing |
349 (4) |
35 (7) |
4 (5) |
||||
| Assisted ventilation category† |
|||||||
| any |
79 (2) |
5 (2) |
0.93 |
0.37–2.34 |
0 (0) |
ND‡ |
|
| none |
4548 (98) |
300 (98) |
ref. |
41 (100) |
|||
| missing |
356 (7) |
31 (9) |
6 (13) |
||||
| Congenital abnormality |
|||||||
| any |
122 (1) |
10 (2) |
1.30 |
0.68–2.51 |
1 (1) |
ND |
|
| none |
8100 (99) |
505 (98) |
ref. |
81 (99) |
|||
| missing |
528 (6) |
45 (8) |
5 (6) |
||||
|
*collected 1980–2004. +collected 1981–2004. †collected 1989–2004. ‡ND = not determined | |||||||
Johnson et al. BMC Pediatrics 2008 8:7 doi:10.1186/1471-2431-8-7 |
|||||||