Research article
Compared to placebo, long-term antibiotics resolve otitis media with effusion (OME) and prevent acute otitis media with perforation (AOMwiP) in a high-risk population: A randomized controlled trial
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* Corresponding author: Amanda J Leach amanda@menzies.edu.au
1 Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia
2 NT Clinical School, Darwin, Northern Territory, Australia
3 Melbourne University, Melbourne, Australia
BMC Pediatrics 2008, 8:23 doi:10.1186/1471-2431-8-23
Published: 2 June 2008Additional files
Additional file 1:
Randomisation details and characteristics of non-randomised and discontinued children. Further details of method of randomisation (e.g. allocation concealment and blinding), reasons for ineligibility to be randomised, and withdrawals.
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Additional file 2:
Table 1. Carriage at randomisation. Nasopharyngeal carriage on the day of randomisation.
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Additional file 3:
Tables 2a & 2b. Ear assessments and carriage during therapy. Table 2a provides number (%) of children with each worst ear status at least once during therapy, and number of examinations (%) with each worst ear status during therapy. Table 2b provides number of swabs (%) with each OM pathogen during therapy.
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Additional file 4:
Tables 3a & 3b. Incidence rate ratios. Discussion of how incidence rate ratio was applied to data from this high-risk population. Table 3a Incidence per child year and incidence rate ratio (IRR) of each worst ear status during therapy. Table 3b: Incidence per child year and incidence rate ratio (IRR) of nasopharyngeal carriage of each OM pathogen¥ during therapy.
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