Table 2

Variations in mean IQ, standard deviations and mortality rates: their affect on sample size calculation.

Total trial size required assuming:


30% mortality

35% mortality


Mean IQ in control group

SD

Mean IQ in cooled group

SD

Mean difference

Number required to detect this difference (80% power, 5% siq.)

80% follow up

75% follow up

80% follow up

75% follow up


75

15

82.5

15

7.5

126

225

240

243

259

80

15

87.5

15

7.5

85

15

92.5

15

7.5

75

20

82.5

20

7.5

224

400

427

431

460

80

20

87.5

20

7.5

85

20

92.5

20

7.5

75

25

82.5

25

7.5

350

625

667

673

718

80

25

87.5

25

7.5

85

25

92.5

25

7.5


Azzopardi et al. BMC Pediatrics 2008 8:17   doi:10.1186/1471-2431-8-17

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