Table 1

Summary of published hypothermia trials, showing effect size

Name of trial

Number in trial

Primary outcome and main secondary outcome

Effect size [assumed for TOBY]


Cool cap trial

218

Death or severe impairment at 18 months

RR 0.82 95%CI 0.66–1.02

NICHD Trial

208

Death or any impairment at 18 months

RR 0.73 95%CI 0.56–0.95

Eicher

65

Death or severe impairment at 12 months

RR 0.62 95%CI 0.41–0.92

TOBY

236

Death or severe impairment at 18 months

[RR 0.70]


Azzopardi et al. BMC Pediatrics 2008 8:17   doi:10.1186/1471-2431-8-17

Open Data