Table 3

Quality assessment of included trials

Included Trial

Gunn 1998

Gluckman 2005

Shankaran 2002

Shankaran 2005

Eicher 2005


Adequacy of method of randomisation

Yes

Computer

generated

Yes

Computer

generated, block

Yes

Computer

generated, block

Yes

Computer

generated, block

Yes

Central

website, block

Concealment of allocation

Yes

Sealed opaque

envelopes

Yes

Sealed opaque

envelopes

Yes

Central data- coordinating center

Yes

Central data- coordinating center

Yes

Central website

Blinding of intervention

None

Due to nature of intervention

None

Due to nature of intervention

None

Due to nature of intervention

None

Due to nature of intervention

None Due to nature of intervention

Blinding of outcome assessors

Not robustly

Yes

No

Yes

Unknown

Completeness of follow-up

Yes (96%)

Yes (93%)

Follow-up not reported#

Yes (98%)

No (68%)#


# Data from this trial was only pooled for analysis of mortality and adverse events

Schulzke et al. BMC Pediatrics 2007 7:30   doi:10.1186/1471-2431-7-30

Open Data