Table 1 |
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History of the most severe diarrhea events caused by microbial infections of intestine of the MPS I patient |
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Age of the patienta |
Detected pathogenic microbial strain(s) |
Antimicrobial agent(s) used |
Special remarks |
|
|
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11 months |
E. coli (group C) |
Trimethoprim and sulphamethoxazole |
Severe diarrhea and vomiting, metabolic acidosis, hospitalization and i.v. rehydration required |
|
21 months (1 y. 9 mo.) |
E. coli (group C) |
Cefuroxime |
Initially applied trimethoprim and sulphamethoxazole did not give a therapeutic effect |
|
27 months (2 y. 3 mo.) |
E. coli (group A) |
Nifuroxazide |
None |
|
28 months (2 y. 4 mo.) |
P. aeruginosa |
None |
Tablets containing Lactobacillus rhamnosus were used to normalize intestinal flora |
|
29 months (2 y. 5 mo.) |
E. coli (group C) |
Furazidin |
None |
|
45 months (3 y. 9 mo.) |
Adenoviruses, C. albicans (in addition, H. parainfluenzae, S. viridans and Neiserria sp. were isolated from oral cavity) |
Cefuroxime, fluconazole, trimethoprim and sulphamethoxazole |
Very severe diarrhea and vomiting, severe dehydration and electrolyte depletion, metabolic acidosis, severe stomatitis. Hospitalization and parenteral nutrition required |
|
49 months (4 y. 1 mo.) |
Adenoviruses |
None |
None |
|
50 months (4 y. 2 mo.) |
E. coli (group C) |
Furazidin, trimethoprim and sulphamethoxazole |
Severe diarrhea, hospitalization and i.v. rehydration required |
|
54 months (4 y. 6 mo.) |
Adenoviruses |
None |
None |
|
55 months (4 y. 7 mo.) |
E. coli (group C) |
Furazidin |
None |
|
56 months (4 y. 8 mo.) |
E. coli (group C), S. aureus, C. albicans |
Furazidin, fluconazole |
None |
|
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a Age of the patient is provided in months as well as in years (y.) and months (mo.) in parentheses |
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Węgrzyn et al. BMC Pediatrics 2005 5:9 doi:10.1186/1471-2431-5-9 |
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