|
Characteristics of Infants Treated for Coagulase-Negative Staphylococcus |
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| Period 1: 1999 (No vancomycin restriction) (n = 45) |
Period 2: 2000–2001 (Vancomycin restriction) (n = 37) |
Difference (95% CI) |
p-value |
|
|
|
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| Baseline characteristics, median (range) |
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| Birth weight, grams |
890 (550, 1750) |
966 (628, 3417) |
39 (-69, 148) |
0.269 |
| Gestational age, weeks |
27 (24, 31) |
27 (24, 41) |
0.0 (-1.0, 1.0) |
0.337 |
| Age at onset of sepsis, days |
13 (4, 74) |
10 (5, 23) |
-2 (-4, 1) |
0.149 |
| Characteristics at onset of sepsis, n (%) |
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| Presence of a central venous line |
18 (40.0) |
21 (56.8) |
16.8 (-4.8, 36.3) |
0.183 |
| Central venous line removal * |
10/18 (55.6) |
10/21 (47.6) |
7.9 (-35.6, 21.7) |
0.751 |
| Receiving total parenteral nutrition |
41 (91.1) |
36 (97.3) |
6.2 (-6.2, 18.2) |
0.372 |
| Prior antibiotics |
43 (95.6) |
33 (89.2) |
-6.4 (-20.6, 5.9) |
0.402 |
| Mean time between sepsis and prior antibiotics, days (sd) |
6.4 (4.4) |
4.7 (3.4) |
-1.7 (-3.5, 5.8) |
0.053 |
| Clinical signs of sepsis, n (%) |
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| Lethargy |
41(91.1) |
25 (67.6) |
-23.5 (-40.5, -6.1) |
0.011 |
| Increased frequency of apneic spells |
35 (77.8) |
23 (62.1) |
-15.6 (-34.4, 4.1) |
0.148 |
| Temperature instability |
23 (51.1) |
17 (45.9) |
-5.2 (-25.6, 15.9) |
0.664 |
| Need for increased ventilatory support |
9/12 (75.0) |
15/16 (93.7) |
18.8 (-8.6, 47.4) |
0.285 |
| Need for intubation in infants not on any ventilatory support |
20/33 (60.6) |
14/21 (66.7) |
6.1 (-19.8, 29.4) |
0.775 |
| Poor perfusion requiring fluid boluses or inotropic support |
15 (33.3) |
11 (29.7) |
-3.6 (-22.7, 16.4) |
0.814 |
|
|
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| Isolate resistant, n (%) |
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|
|
||||
| Cloxacillin |
34 (75.5) |
29 (78.4) |
2.8 (-15.8, 20.4) |
0.799 |
| Gentamicin |
30 (66.7) |
26 (72.2) |
3.6 (-16.4, 22.7) |
0.635 |
| Both cloxacillin and gentamicin |
23 (51.1) |
26 (72.2) |
21.1 (-0.03, 39.6) |
0.113 |
|
* Percentage based on infants with a central venous line | ||||
Lawrence et al. BMC Pediatrics 2005 5:49 doi:10.1186/1471-2431-5-49 |
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