Table 2 |
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|
HPRT mutational spectra in newborns with and without exposure to tobacco smoke metabolites in utero |
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|
a) distribution of mutant clones |
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|
maternal exposure |
study |
total independent mutants |
small mutations (%) |
deletions, rearrangements (%) |
VDJ recombinant deletions (%) |
P1 |
|
unexposed |
Finette et al [23] |
30 |
10 (33) |
14 (47) |
6 (20) |
|
|
mixed |
McGinniss et al [11] |
41 |
7 (17) |
14 (34) |
20 (49) |
0.039 |
|
mixed |
Manchester et al [21] |
38 |
13 (34) |
16 (42) |
9 (24) |
0.91 |
|
passively exposed |
Finette et al [23] |
35 |
17 (49) |
6 (17) |
12 (34) |
0.036 |
|
b) mutation frequencies for three classes of mutants based on individual studies |
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|
maternal exposure |
study |
overall mean Mf ± SD (× 10-6) |
small mutations Mf (× 10-6) |
deletions, rearrangements Mf (× 10-6) |
VDJ recombinant deletions Mf (× 10-6) |
P2 |
|
unexposed |
Finette et al [22,23] |
0.72 ± 0.53 |
0.24 |
0.34 |
0.14 |
|
|
mixed |
McGinniss et al [11] |
0.64 ± 0.40 |
0.11 |
0.22 |
0.31 |
0.003 |
|
mixed |
Manchester et al [21] |
1.32 ± 1.093 |
0.45 |
0.56 |
0.31 |
< 0.001 |
|
passively exposed |
Finette et al [22,23] |
1.18 ± 1.284 |
0.57 |
0.20 |
0.40 |
0.002 |
|
c) mutation frequencies for three classes of mutants based on pooled data5 |
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|
unexposed |
Finette et al [22,23] |
0.73 ± 0.51 |
0.24 |
0.34 |
0.15 |
|
|
mixed |
McGinniss et al [11] |
0.99 ± 0.95 |
0.17 |
0.34 |
0.48 |
0.008 |
|
mixed |
Manchester et al [21] |
0.99 ± 0.953 |
0.34 |
0.42 |
0.24 |
0.037 |
|
passively exposed |
Finette et al [22,23] |
1.38 ± 1.364 |
0.67 |
0.24 |
0.47 |
< 0.001 |
|
|
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|
1χ2 2t tests on ln transformed data 3excluding outlier with HPRT Mf of 14.7 × 10-6 4excluding outlier with HPRT Mf of 45.3 × 10-6 5for the purposes of this analysis the data of McGinniss et al [11] was pooled with that of Manchester et al [21] and Finette et al [22,23] to yield a single Mf. |
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|
Grant BMC Pediatrics 2005 5:20 doi:10.1186/1471-2431-5-20 |
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