Table 1

Summary of tests used for different clinical applications

Aim

Current Reference standard

Tests

Advantage over the reference standard


Localisation of infection

Tc-99 m-DMSA renal scintigraphy

Clinical features

Laboratory-based tests

Ultrasound

All less invasive, no exposure to ionising radiation

Detection of reflux

Micturating cystourethrography (MCUG)

Ultrasound

Less invasive, no exposure to ionising radiation

Indirect radionuclide cystography

Single procedure test for reflux and scarring

Prediction of renal scarring

Follow-up Tc-99 m-DMSA renal scintigraphy

Clinical features

Would allow earlier prediction of children at risk of renal scarring

Ultrasound

MCUG

Acute DMSA renal scintigraphy

Detection of renal scarring

Tc-99 m-DMSA renal scintigraphy

Ultrasound

Less invasive, no exposure to ionising radiation

Intravenous pyelography (IVP)

Provides a detailed anatomic map, considered essential where surgery is planned.

Radionuclide cystography

Advocated as a single procedure test for reflux and scarring


Westwood et al. BMC Pediatrics 2005 5:2   doi:10.1186/1471-2431-5-2

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