Research article

Randomized controlled trials in pediatric complementary and alternative medicine: Where can they be found?

Margaret Sampson¹ , Kaitryn Campbell² , Isola Ajiferuke³ and David Moher^1,4

¹  Chalmers Research Group, Children's Hospital of Eastern Ontario Research Institute, Canada

²  The Ottawa Hospital, Canada

³  Faculty of Information and Media Studies, The University of Western Ontario, Canada

⁴  Department of Pediatrics, University of Ottawa, Canada

author email corresponding author email

BMC Pediatrics 2003, 3:1doi:10.1186/1471-2431-3-1

Published:	14 February 2003

Abstract

Background

The safety and effectiveness of CAM interventions are of great relevance to pediatric health care providers. The objective of this study is to identify sources of reported randomized controlled trials (RCTs) in the field of pediatric complementary and alternative medicine (CAM).

Methods

Reports of RCTs were identified by searching Medline and 12 additional bibliographic databases and by reviewing the reference lists of previously identified pediatric CAM systematic reviews.

Results

We identified 908 reports of RCTs that included children under 18 and investigated a CAM therapy. Since 1965, there has been a steady growth in the number of these trials that are being published. The four journals that published the most reported RCTs are The American Journal of Clinical Nutrition, Pediatrics, Journal of Pediatrics, and Lancet. Medline, CAB Health, and Embase were the best database sources for identifying these studies; they indexed 93.2%, 58.4% and 42.2 % respectively of the journals publishing reports of pediatric CAM RCTs.

Conclusions

Those working or interested in the field of pediatric CAM should routinely search Medline, CAB Health and Embase for literature in the field. The four core journals identified above should be included in their collection.