Table 2

Anthropometric and laboratory measurements of the children and adolescents participating in HELIOS, for all participants together and stratified according to SDS-BMI group and Spearman’s rank correlations
Total (n = 80) SDS-BMI < median (n = 39) SDS-BMI >= median (n = 41) Spearman’s R with SDS-BMI Spearman’s R with EQ-5D
Age (y) 14.8 (2.3) 14.4 (2.4) 15.2 (2.2) 0.19 0.05
Male/Female (%) 33.8/66.2 17.9/82.1** 48.8/51.2** NA NA
SDS-BMI 3.4 (0.4) 3.1 (0.2)** 3.7 (0.3)** - −0.03
SDS-waist circumference 3.6 (0.3) 3.4 (0.2)** 3.8 (0.3)** 0.80** −0.07
BIS
  Fat mass (%) 52.3 (4.4) 50.5 (3.8)** 53.9 (4.4)** 0.32** −0.13
Systolic blood pressure (mmHg) 121.9 (12.8) 117.5 (11.1)** 126.1 (13.0)** 0.37** −0.09
Diastolic blood pressure (mmHg) 76.8 (11.1) 74.9 (9.4) 78.7 (12.4) 0.19 0.03
Puberty stage (%)1
  Prepubertal 8.8 12.8 4.9 NA NA
  Pubertal 48.8 53.8 43.9 NA NA
  Postpubertal 42.5 33.3 51.2 NA NA
Fasting plasma insulin (pmol/L) 98.6 (65.1) 72.6 (40.4)** 122.7 (74.4)** 0.49** −0.12
Fasting plasma glucose (mmol/L) 4.7 (0.3) 4.6 (0.3)* 4.8 (0.3)* 0.19 −0.10
2-h plasma glucose (mmol/L) 5.8 (1.2) 5.8 (1.4) 5.9 (0.9) 0.14 −0.22†
Total cholesterol (mmol/L) 3.8 (0.7) 3.7 (0.8) 3.8(0.7) 0.09 −0.13
HDL-cholesterol (mmol/L) 1.0 (0.2) 1.1 (0.2) † 1.0 (0.2) † −0.22† −0.10
LDL-cholesterol (mmol/L) 2.3 (0.6) 2.2 (0.6) 2.3 (0.7) 0.00 −0.08
Triglycerides (mmol/L) 1.0 (0.6) 0.8 (0.4)** 1.2 (0.6)** 0.37** −0.18
HS-CRP (mg/l) 5.0 (4.6) 4.4 (4.6) 5.5 (4.6) 0.22 0.07
HbA1C (DCCT %) 5.5 (0.3) 5.5(0.3) 5.5 (0.2) 0.05 0.07
HOMA-IR 3.0 (2.1) 2.2 (1.3)** 3.8 (2.4)** 0.48** −0.15

Data are mean (SD).

SD – standard deviation; SDS-BMI – standard deviation of body mass index; SDS-waist circumference – standard deviation of waist circumference; BIS – Bio-electrical impedance spectroscopy; HDL – high-density lipoprotein; LDL – low-density lipoprotein; HS-CRP - high sensitive C-reactive protein; HbA1C – hemoglobin type A1C; HOMA-IR – homeostasis model assessment for insulin resistance; EQ-5D – EQ-5D descriptive system; R – correlation.

Median is 3.46.

† P value = 0.05.

* P value <0.05.

** P value < 0.01.

1 Three stages based on Tanner stages: ‘prepubertal’ equals G/M1&P1; ‘postpubertal’ equals G/M5&P5; ‘pubertal’ equals all other Tanner stages.

NA Not applicable.

Makkes et al.

Makkes et al. BMC Pediatrics 2013 13:62   doi:10.1186/1471-2431-13-62

Open Data