Table 5

Predicting abnormal aEEG at 3 or 6 hours: assessments at 1 and 3 – 5 hours
Encephalopathy assessment method n Abnormal aEEG n (%) Sensitivity (95%CI) Specificity (95%CI) LR +(95%CI) LR - (95%CI) LR Test (Odds ratio) (95%CI)
Moderate-severe encephalopathy age 1 hour Yes 31 25 (81) 89% 60% 2.23 0.18 12.5
No 12 3 (25) (72 – 98) (32 – 84) (1.19 – 4.2) (0.06 – 0.56) (2.71 – 56.89)
Moderate-severe encephalopathy age 3 – 5 hours Yes 29 26 (90) 93% 80% 4.64 0.09 52
No 14 2 (14) (77 – 99) (52 – 96) (1.68 – 12.84) (0.02 – 0.35) (8.24 – 321.56)
Thompson score ≥ 8 age 3 – 5 hours Yes 28 25 (89) 89% 80% 4.46 0.13 33.33
No 15 3 (20) (72 – 98) (52 – 96) (1.61 – 12.38) (0.04 – 0.4) (6.16 – 180.87)
Thompson score ≥ 7 age 3 – 5 hours Yes 31 26 (84) 93% 67% 2.79 0.11 26
No 12 2 (17) (77 – 99) (38 – 88) (1.35 – 5.74) (0.03 – 0.43) (4.67 – 139.13)
Thompson score ≥ 6 age 3 – 5 hours Yes 34 26 (76) 93% 47% 1.74 0.15 11.38
No 9 2 (22) (77 – 99) (21 – 73) (1.07 – 2.83) (0.04 – 0.65) (2.15 – 57.78)
Thompson score ≥ 5 age 3 – 5 hours Yes 39 28 (72) 100% 27% 1.37 a 0.06 a 22.3 a
No 4 0 (0) (88 – 100) (8 – 55) (1 – 1.86) (0 – 1.07) (1.11 – 448.4)
Thompson score ≥ 8 age 3 – 5 hours Yes 30 26 (87) 93% 73% 3.48 0.1 35.75
No 13 2 (15) (77 – 99) (45 – 92) (1.5 – 8.11) (0.02 – 0.38) (6.13 – 201.31)
Thompson score ≥ 7 age 3 – 5 hours Yes 32 27 (84) 96% 67% 2.76 a 0.08 a 35 a
No 11 1 (9) (82 – 100) (38 – 88) (1.39 – 5.46) (0.02 – 0.39) (5.03 – 243.64))
Thompson score ≥ 6 age 1 hour Yes 38 28 (74) 100% 33% 1.5 a 0.05 a 29.86 a
No 5 0 (0) (88 – 100) (12 – 62) (1.05 – 2.14) (0 – 0.85) (1.52 – 587.98)
Thompson score ≥ 5 age 1 hour Yes 39 28 (72) 100% 27% 1.37 a 0.06 a 22.3 a
No 4 0 (0) (88 – 100) (8 – 55) (1 – 1.86) ( 0 – 1.07) (1.11 – 448.4)

aEEG: amplitude integrated electro-encephalogram, LR: Likelihood ratio.

a : When zero count cells are present, LR is estimated using a substitution formula: 0.5 is added to all cell frequencies before calculation.

Horn et al.

Horn et al. BMC Pediatrics 2013 13:52   doi:10.1186/1471-2431-13-52

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