Table 1

Indications for initiation of treatment or prophylaxis with the two drugs
Ciprofloxacin treatment (5 NICUs) N. NICUs
First line therapy (even in association) of:
 Culture-proven sepsis due to multi-drug resistant organisms that are sensitive to ciprofloxacin 5 (100%)
 Sepsis resulting from a suspected multi-drug resistant strain infection 1
 Sepsis resistant to first line empirical antibiotic therapy (other than ciprofloxacin) 1
 Severe sepsis resistant to first line empirical antibiotic therapy (other than ciprofloxacin) 1
Fluconazole prophylaxis (30 NICUs)
Birth gestational age 21 (70%)
 <26 weeks 2
 <28 weeks 10
 <30 weeks 7
 other 2
Birth weight 27 (90%)
 <750 g 1
 <1000g 13
 <1500 13
Neonate receiving antibiotics for a certain number of days 14 (47%)
 >2 days 6
 >7 days 5
 >14 days 3
Presence of a central venous catheter (CVC) 22 (73%)
 Peripherally inserted CVC 18
 Umbilical venous CVC 15
 Only CVC used >7 days 7
 Only CVC used >14 days 1
 Surgically inserted CVC 5
Endotracheal intubation 10 (33%)
 Only if intubated >7 days 8
 Only if intubated >14 days 0
Total parenteral nutrition (TPN) 14 (47%)
 Only if TPN used >7 days 11
 Only if TPN used >14 days 1
Abdominal surgery 12 (40%)
Abdominal disease 7 (23%)
 Necrotizing enterocolitis 4
 Focal bowel perforation 3
 Gastroschisis 1
 Omphalocele 0
Antibiotics being used 5 (17%)
 Only if >7 days 5
 Only if >14 days 0
Colonization status 11 (37%)
 Scheduled surveillance cultures+/− other cultures 7
 Determined by clinical features 4
Fluconazole treatment (17 NICUs)
Sepsis with identification of Candida spp. in cultures of central samples (blood, cerebrospinal fluid, …) 15 (88%)
Sepsis with documented fungal colonization 12 (71%)
Sepsis resistant to first line empirical antibiotic therapy 7 (41%)
Severe sepsis 1 (6%)

Note: some answers were missing so sum is not always equal to number of NICUs replying.

Pandolfini et al.

Pandolfini et al. BMC Pediatrics 2013 13:5   doi:10.1186/1471-2431-13-5

Open Data