Table 1

Laboratory work up in suspected pediatric NAFLD
Laboratory workup What to rule out
Basic profile: Full blood count, Liver function tests, fasting glucose and insulin, urea and electrolytes, coagulation, INR, iron, ferritin, uric acid
Lipid profile Dyslipidemia/Familial hypercholesterolemia/ Cholesterol ester storage disease
Lipoproteins Abetalipoproteinaemia
Glucose tolerance test (OGTT), glycosylated hemoglobin Insulin resistance/Type 2 Diabetes Mellitus (DM2)
Thyroid function tests Hypothyroidism
Ceruloplasmin level Wilson Disease
Viral hepatitis panel Viral - hepatitis (HBV, HCV)
C-Reactive-Protein + consider EBV, CMV immune state profile Acute systemic disease
Sweat test Cystic Fybrosis
Anti-Transglutaminase IgA and total IgA Coeliac disease
CPK Muscular Dystrophy
Alpha-1-antitrypsin serum level Alpha-1-antitrypsin deficiency
Serum lactate +/− amino and organic acids +/− plasma-free fatty acids +/− acyl carnitine profile Metabolic diseases (Galactosaemia -in infants-, hereditary fructose intolerance, glycogen storage disease (Type VI and IX), others
Serum Immuniglobulin, Liver autoantibodies Autoimmune hepatitis
Specific tests as suggested by history, consider: Drug toxicity, Parenteral Nutrition, Protein malnutrition, others

Laboratory tests in suspected pediatric NAFLD, and correspondent ruled out diseases of other etiology.

Giorgio et al.

Giorgio et al. BMC Pediatrics 2013 13:40   doi:10.1186/1471-2431-13-40

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