Table 1

Criteria for organ dysfunction
Cardiovascular Despite intravenous application of >40 ml/kg isotonic volume in 1 hour persisting:
· Decrease in BP (hypotension) <5th percentile for age or systolic BP < 2 SD below normal for age
· Need for vasocative drugs to maintain BP in normal range (use of dopamine in dose >5 μg/kg/min or epinephrine, norepinephrine, or dobutamine at any dose)
· Two of the following
- Metabolic acidosis (base deficit >5 mmol/l)
- Arterial lactate >2 times upper limit of normal
- Oliguria: urine output <0.5 ml/kg/h
- Prolonged capillary refill >5 sec.
- Core to peripheral body temperature difference >3°C
Respiratory · Oxygenation index <300 in absence of cyanotic heart disease or preexisting lung disease
· PaCO2 >65 mmHg or increase of >20 mmHg over baseline
· Proven need or FiO2 >0.5 in order to maintain saturation ≥92%
· Need for nonelective mechanical ventilation (invasive or non-invasive)
Neurologic · Glasgow Coma Scale (GCS) ≤11
· Acute change in mental status with decrease in GCS ≥3 points from abnormal baseline
Hematologic · Platelet count < 80.000/mm3 or decline of 50% in platelet count from highest value recorded over the past 3 days (for chronic hematology/oncology patients)
International Normalized Ratio >2
Renal Serum creatinine ≥ 2 times upper limit of normal for age or 2-fold increase in baseline creatinine
Hepatic · Total bilirubin ≥ 4 mg/dL (not applicable for newborn)
ALT 2 times upper limit of normal age

This table shows the diagnostic criteria for cardiovascular, respiratory, neurologic, hematologic, renal, and hepatic dysfunction according to the International pediatric sepsis consensus conference [16]. BP denotes blood pressure, GCS Glasgow Coma Scale, ALT alanine aminotransferase.

Boehne et al.

Boehne et al. BMC Pediatrics 2013 13:21   doi:10.1186/1471-2431-13-21

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