Table 4

Comparison of abnormal values of diagnostic markers between ALL and JIA patients
Diagnostic markers All patients n/N (%) ALL n/N (%) JIA n/N (%) p-value (ALL versus JIA) Sensitivity Specificity PPV NPV LR+ LR-
WBC count 59/113 (52.2) 26/45 (57.8) 33/68 (48.5) 0.345
Neutrophil count 23/101 (22.8) 21/40 (52.5) 2/61 (3.3) 0.000 52.5% 96.7% 91.3% 75.6% 15.9 0.5
Platelet count 87/113 (77.0) 36/45 (80.0) 51/68 (75) 0.650
Hb 32/113 (28.3) 26/45 (57.8) 6/68 (8.8) 0.000 57.8% 91.2% 81.2% 76.5% 6.6 0.5
LDH 70/92 (76.1) 37/43 (86.0) 33/49 (67.3) 0.050
ESR 78/95 (82.1) 24/27 (88.9) 54/68 (79.4) 0.379
CRP 73/99 (73.7) 26/38 (68.4) 47/61 (77.0) 0.358
ANA 34/76 (44.7) 2/14 (14.3) 32/62 (51.6) 0.016 14.3% 48.4% 5.8% 71.4% 0.3 1.8
IgG 34/96 (35.4) 12/39 (30.8) 22/57 (38.6) 0.517
IgM 6/96 (6.3) 2/39 (5.1) 4/5 (7.0) 1.000
IgA 23/96 (24.0) 15/39 (38.5) 8/57 (14.0) 0.008 38.5% 86% 65.2% 67.1% 2.8 0.7
C3 42/82 (51.2) 17/28 (60.7) 25/54 (46.3) 0.250
C4 23/81 (18.4) 14/28 (50.0) 9/53 (17.0) 0.004 50% 83% 60.8% 75.8% 2.9 0.6
Anti-EBV IgM 8/50 (16.0) 7/36 (19.4) 1/14 (7.1) 0.414
Anti-EBV IgG 35/51 (68.6) 27/36 (75.0) 8/15 (53.3) 0.187
Anti-EA EBV IgG 12/40 (30.0) 12/30 (40.0) 0/10 (0) 0.019 40.0% 100% 1.0% 35.7% - 0.6
Anti-CMV IgM 4/40 (10.0) 2/30 (6.7) 2/10 (20.0) 0.256
Anti-CMV IgG 24/39 (61.5) 22/29 (75.9) 2/10 (20.0) 0.003 75.9% 80.0% 91.6% 53.3% 3.8 0.3

Agodi et al.

Agodi et al. BMC Pediatrics 2013 13:15   doi:10.1186/1471-2431-13-15

Open Data