Table 5

Fixed effects model data and analyses
Exposure variable Outcome or subgroup Studies Participants Statistical method Effect estimate
Overweight/Obesity 1.1 Overweight vs. physician-diagnosed asthma at age 9+ (Total) 3 12237 Risk ratio (IV, Fixed, 95% CI) 1.35 [1.15, 1.58]
1.2 Obese vs. physician-diagnosed asthma in children ages 8–18 years (Total) 2 15688 Risk ratio (IV, Fixed, 95% CI) 1.50 [1.22, 1.83]
1.3 Overweight vs. physician-diagnosed asthma at age 9+ (Boys) 3 6180 Risk ratio (IV, Fixed, 95% CI) 1.41 [1.05, 1.88]
1.4 Overweight vs. physician-diagnosed asthma at age 9+ (Girls) 3 6057 Risk ratio (IV, Fixed, 95% CI) 1.19 [0.91, 1.56]
1.5 Obese vs. physician-diagnosed asthma in children ages 8–18 years (Boys) 2 4005 Risk ratio (IV, Fixed, 95% CI) 1.40 [1.01, 1.93]
1.6 Obese vs. physician-diagnosed asthma in children ages 8–18 years (Girls) 2 3839 Risk ratio (IV, Fixed, 95% CI) 1.53 [1.09, 2.14]
1.7 BMI at age 3 vs. incident asthma at 6 years of age 1 249 Odds ratio (IV, Fixed, 95% CI) 1.04 [0.50, 2.16]
1.8 BMI at age 3 vs. incident asthma at 8 years of age 1 229 Odds ratio (IV, Fixed, 95% CI) 1.51 [0.69, 3.30]
1.9 BMI at age 5 vs. incident asthma at 6 years of age 1 255 Odds ratio (IV, Fixed, 95% CI) 0.91 [0.45, 1.84]
1.10 BMI at age 5 vs. incident asthma at 8 years of age 1 235 Odds ratio (IV, Fixed, 95% CI) 1.31 [0.61, 2.81]
BMI Z-score 2.1 BMI Z-score vs. any physician diagnosed asthma (Total) 2 25280 Risk ratio (IV, Fixed, 95% CI) 1.03 (0.97, 1.10)
2.2 BMI Z-score vs. any physician diagnosed asthma (Boys) 2 6442 Risk ratio (IV, Fixed, 95% CI) 0.92 [0.81, 1.04]
2.3 BMI Z-score vs. any physician diagnosed asthma (Girls) 2 6198 Risk ratio (IV, Fixed, 95% CI) 1.19 [1.06, 1.34]
2.4 Asthma at age 14 years (Total) 1 2812 Odds ratio (IV, Fixed, 95% CI) 1.01 [0.92, 1.11]
2.5 Asthma at age 14 years (Boys) 1 1472 Odds ratio (IV, Fixed, 95% CI) 0.87 [0.75, 1.01]
2.6 Asthma at age 14 years (Girls) 1 1340 Odds ratio (IV, Fixed, 95% CI) 1.14 [1.00, 1.30]
BMI Z-score 3.1 BMI at entry vs. asthma with any wheeze (Boys) 1 4970 Risk ratio (IV, Fixed, 95% CI) 1.05 [0.83, 1.33]
3.2 BMI at entry vs. asthma with any wheeze (Girls) 1 4858 Risk ratio (IV, Fixed, 95% CI) 1.43 [1.09, 1.88]

Egan et al.

Egan et al. BMC Pediatrics 2013 13:121   doi:10.1186/1471-2431-13-121

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