Table 2

Morbidity and mortality in ELBW infants
Group 1 Group 2 Group 3 p-value*
(1997–2000) (2001–2005) (2006–2009)
(N = 65) (N = 178) (N = 172)
CRIB 3 (1–8) 4 (2–7) 4 (2–8) 0.722
RDS 36 (55.4%) 99 (55.6%) 103 (59.9%) 0.432
Sepsis 28 (43.1%) 85 (47.8%) 65 (37.8%) 0.215
NEC 6 (9.2%) 12 (6.7%) 12 (7.0%) 0.644
IVH 18 (27.7%) 36 (20.2%) 43 (25.0%) 0.999
- Grades III/IV 11 (16.9%) 16 (9.0%) 18 (10.5%) 0.307
PVLM 1 (4.5%) 5 (5.6%) 4 (2.3%) 0.245
PDA 17 (26.2%) 56 (31.5%) 75 (43.6%) 0.004
- Surgical closure 1 (1.5%) 12 (6.7%) 18 (10.5%) 0.058
Parenteral nutrition (day) 13 (7–20) 9 (6–13) 8 (6–12) 0.009
Formula feed 24 (45.3%) 40 (25.2%) 17 (11.1%) <0.001
Mortality** 23 (35.4%) 43 (24.2%) 40 (23.3%) 0.102
SWsBPD 38 (58.5%) 132 (74.2%) 129 (75.0%) 0.032
In survivors: n = 42 n = 135 n = 132
Mild BPD 8 (19.0%) 34 (25.2%) 39 (29.5%) 0.378
Moderate or severe BPD 4 (9.5%) 3 (2.2%) 3 (2.3%) 0.046
Weight at discharge (g) 2148 (2100–2250) 2060 (1900–2160) 2013 (1900–2193) <0.001
Length of stay (days) 83 (64–102) 70 (59–83) 71 (59–85) 0.007
Weight gain (g/kg/day) 16 (14–18) 17 (15–19) 17 (15–19) 0.233

CRIB: clinical risk index for babies; RDS: respiratory distress syndrome; NEC: necrotizing enterocolitis; IVH: peri-intraventricular hemorrhage; PVLM: periventricular leukomalacia; PDA: patent ductus arteriosus; SWsBPD: survival without significant bronchopulmonary dysplasia.

Median (IQR: 25th-75th percentile), number (%).

* Kruskal-Wallis or chi-square test; ** All deaths occurred in the NICU.

Botet et al.

Botet et al. BMC Pediatrics 2012 12:63   doi:10.1186/1471-2431-12-63

Open Data