Table 4

Outcome prediction at birth: sensitivity analyses excluding infants that died in delivery room (n = 130): Uni- and multivariate association of clinical and demographic parameters known at birth with mortality, adverse outcome and unfavourable outcome
MORTALITY Univariate model† Multivariate model‡
OR(95%-CI) p-value OR(95%-CI) p-value
Gestational age (weeks) 0.47 (0.41 - 0.55) <0.001 0.46 (0.39 - 0.54) <0.001
BW z-score 0.66 (0.56 - 0.77) <0.001 NA
BW z-score < −2 6.92 (2.89 - 16.59) <0.001 10.09 (4.01 - 25.40) <0.001
BW z-score2 to1 2.02 (1.35 - 3.02) <0.001 2.52 (1.63 - 3.90) <0.001
Male sex 1.13 (0.86 - 1.49) 0.38 1.16 (0.86 - 1.57) 0.33
Outborn 1.15 (0.64 - 2.06) 0.65 NA
Antenatal corticosteroids 0.52 (0.39 - 0.70) <0.001 0.55 (0.41 - 0.76) <0.001
Caesarean delivery 0.77 (0.55 - 1.06) 0.1 NA
Multiple pregnancy 0.94 (0.69 - 1.29) 0.72 1.28 (0.90 - 1.81) 1.17
ADVERSE OUTCOME Univariate model† Multivariate model‡
OR(95%-CI) p-value OR(95%-CI) p-value
Gestational age (weeks) 0.56 (0.49 - 0.65) <0.001 0.55 (0.47 - 0.64) <0.001
BW z-score 0.73 (0.62 - 0.85) <0.001 NA
BW z-score < −2 4.99 (1.98 - 12.56) <0.001 6.74 (2.58 - 17.60) <0.001
BW z-score2 to1 1.82 (1.22 - 2.72) 0.003 2.20 (1.44 - 3.36) <0.001
Male sex 1.29 (0.98 - 1.69) 0.066 1.35 (1.01 - 1.80) 0.041
Outborn 1.34 (0.73 - 2.47) 0.34 NA
Antenatal corticosteroids 0.58 (0.44 - 0.78) <0.001 0.61 (0.45 - 0.83) 0.002
Caesarean delivery 0.79 (0.57 - 1.09) 0.15 NA
Multiple pregnancy 0.91 (0.67 - 1.23) 0.55 1.17 (0.85 - 1.63) 0.34
UNFAVOURABLE OUTCOME Univariate model† Multivariate model‡
OR (95%-CI) p-value OR(95%-CI) p-value
Gestational age (weeks) 0.60 (0.52 - 0.68) <0.001 0.59 (0.51 - 0.68) <0.001
BW z-score 0.75 (0.64 - 0.87) <0.001 NA
BW z-score < −2 11.32 (2.60 - 49.16) 0.001 15.24 (3.43 - 67.71) <0.001
BW z-score2 to1 1.47 (0.96 - 2.19) 0.059 1.69 (1.12 - 2.57) 0.013
Male sex 1.30 (1.00 - 1.67) 0.049 1.35 (1.02 - 1.78) 0.033
Outborn 1.65 (0.87 - 3.15) 0.13 NA
Antenatal corticosteroids 0.64 (0.48 - 0.86) 0.002 0.66 (0.49 - 0.89) 0.006
Caesarean delivery 0.96 (0.70 - 1.33) 0.82 NA
Multiple pregnancy 1.01 (0.76 - 1.35) 0.94 1.29 (0.94 - 1.76) 0.11

The table gives all parameters that showed an unequal distribution among groups as shown in Table I or that are known from previous publications to act as confounders. † The univariate model is adjusted for study centre and year group. ‡ The multivariate model contains all parameters that were associated with the outcome in the univariate model.

OR, Odd’s ratio; CI, confidence interval; BW, birth weight.

Schlapbach et al.

Schlapbach et al. BMC Pediatrics 2012 12:198   doi:10.1186/1471-2431-12-198

Open Data