Table 3

Prevalence and odds ratios (and 95% CI) of asthma and atopic sensitization at age 8–9 by mode of delivery, stratified by family history of allergy
NO FAMILY HISTORY OF ALLERGY FAMILY HISTORY OF ALLERGY Effect modification p-value‡
Vaginal Prevalence %(95%CI) Caesarean Prevalence % (95%CI) Unadjusted Odds Ratios (95% CI) Adjusted Odds Ratios† (95% CI) Vaginal Prevalence % (95%CI) Caesarean Prevalence % (95%CI) Unadjusted Odds Ratios (95% CI) Adjusted Odds Ratios† (95% CI)
All children* N=929 N=413 N=531 N=259
Ever Wheeze 15.2(12.9-17.5) 19.9 (16.0-23.8) 1.38 (1.02-1.87) 1.45 (1.05-2.00) 37.3 (33.2-41.4) 44.8 (38.7-50.9) 1.36 (1.00-1.83) 1.27 (0.92-1.75) 0.55
Current Wheeze 4.1 (2.8-5.4) 6.8 (4.4-9.2) 1.70 (1.03-2.82) 1.54 (0.89-2.64) 13.7 (10.8-16.6) 17.8 (13.1-22.5) 1.37 (0.92-2.06) 1.07 (0.69-1.66) 0.31
Ever Asthma 10.5 (8.5-12.5) 13.3 (10.0-16.6) 1.30 (0.91-1.84) 1.40 (0.96-2.05) 25.6 (21.9-29.3) 34.4 (28.6-40.2) 1.54 (1.11-2.12) 1.42 (1.00-2.01) 0.96
Active Asthma 2.7 (1.7-3.7) 3.4 (1.7-5.1) 1.26 (0.65-2.46) 1.19 (0.57-2.46) 9.6 (7.1-12.1) 13.5 (9.3-17.7) 1.49 (0.94-2.36) 1.25 (0.76-2.07) 0.90
Sub-group* N=289 N=137 N=204 N=89
Atopic sensitization 14.8 (10.8-18.8) 15.0 (9.2-20.8) 1.04 (0.60-1.81) 1.16 (0.64-2.11) 12.1 (7.8-16.4) 24.2 (15.8-32.6) 2.42 (1.30-4.96) 2.62 (1.38-5.00) 0.06

† Adjusted for sex, country of birth, district of residence, urban/rural residence, birth order, parental level of education, parental smoking at home, mother smoking during pregnancy, birth weight < 2500 gr., exclusive breastfeeding for more than 2 months, nursery attendance in the first year of life, bedroom sharing with older sibling. ‡ P-value for effect modification by family history of allergy in multivariable models. * Numbers reflect missing values on some variables.

Kolokotroni et al.

Kolokotroni et al. BMC Pediatrics 2012 12:179   doi:10.1186/1471-2431-12-179

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